Wounds and Injuries
Conditions
Interventions
The objective of this study is to evaluate soft tissue repair at the donor site of gingival grafts treated with green tea gel and hyaluronic acid or adhesive dressings. The sample will consist of 45 h
FIB – Use of fibrin sponge for palate protection
CUR – Use of adhesive dressing for wound protection. Patients will be clinically assessed at 3, 7, 14, and 30 days after gingival tissue removal from the palate to evaluate pain using the VAS scale, e
Sponsors
Universidade Federal de Uberlândia
Universidade Federal de Uberlândia
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 60 years; Good oral hygiene (Plaque Index < 20%); Systemic health; Probing depth less than 3 mm in the affected areas of the recipient site; Isolated or multiple gingival recession with interproximal tissue filling the entire interproximal space; Absence of keratinized mucosa associated with teeth or dental implants
Exclusion criteria
Exclusion criteria: Patients with periodontal disease; Patients with systemic diseases or conditions or who use medications that alter bone metabolism (except for compensated diabetics); Uncontrolled diabetics (glycated hemoglobin above 8%); Pregnant or breastfeeding women; Heavy smokers (more than 10 cigarettes per day); Patients who use illicit drugs; Presence of periapical lesions; Patients who have used corticosteroids, chemotherapeutic agents, and immunomodulators in the last 6 months; Patients who did not agree to return for follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study will be the closure of the donor area with epithelial tissue. It is expected that the adhesive dressing and the green tea and hyaluronic acid-based gel will accelerate defect closure by 30% more than the group where donor areas are treated with fibrin sponges, up to the 14th day of evaluation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain and confort assessment will be performed using the VAS scale. It is expected that the adhesive dressing and the green tea and hyaluronic acid-based gel will reduce the sensation of pain by 2 points on the VAS scale up to the 14th day of assessment in the group where donor sites will be treated with fibrin sponge;Analgesic consumption will be tracked through patient intake of these medications. It is expected that the adhesive dressing and the green tea and hyaluronic acid-based gel will reduce medication consumption by up to 3 tablets by the 3rd evaluation day compared to the group where donor sites will be treated with fibrin sponge.;Biological markers of wound healing will be evaluated using the ELISA test. It is expected that the adhesive dressing and the green tea and hyaluronic acid-based gel will increase the expression of wound healing markers by more than 10% compared to the group where donor sites will be treated with fibrin sponge | — |
Countries
Brazil
Contacts
Public ContactGuilherme Oliveira
Universidade Federal de Uberlândia
Outcome results
None listed