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Study on the use of electrical stimulation of the brain and spinal cord to improve the strength of respiratory muscles

Study of the use of Bilateral Anodal and Cathodal Direct Current Stimulation under the Primary motor cortex and spinal cord in gaining respiratory muscle strength and endurance: a double-blind, randomized clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
REBEC
Registry ID
RBR-5nwn9xf
Enrollment
Unknown
Registered
2025-07-09
Start date
2024-11-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Stimulation

Interventions

This is a randomized, controlled, two-arm, double-blind clinical study. The study will apply Transcranial Direct Current Stimulation (tDCS) to the bilateral primary motor area (M1), using two electros

Sponsors

Universidade Federal do Amazonas
Lead Sponsor
Universidade Federal do Amazonas
Collaborator

Eligibility

Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Both sexes. Distributed into two distinct age groups the young group composed of individuals aged between 18 and 25 years, and the elderly group, composed of individuals aged between 60 and 75 years. All participants, regardless of the group, must have a body mass index (BMI) between 17 and 24.9, normal lung function, with forced expiratory volume in one second (FEV1) values ??greater than 80%, forced vital capacity (FVC) greater than 80% and FEV1/FVC ratio greater than 70%. In addition, volunteers must not have diagnosed cardiovascular diseases, nor motor alterations in the upper limbs that prevent the assessment of isometric handgrip strength

Exclusion criteria

Exclusion criteria: Individuals from both groups who have diagnosed chronic respiratory diseases, as well as those who are smokers or ex-smokers who have quit smoking for less than six months. Participants who abuse alcohol (alcoholics), who have been diagnosed with type I or type II diabetes, or who have any other metabolic syndrome or diagnosed rheumatic disease. Specifically for the elderly group, individuals with cognitive impairment will be excluded, as defined by scores below 18 points on the Mini-Mental State Examination (MMSE), previously administered by an experienced examiner

Design outcomes

Primary

MeasureTime frame
It is expected to find the effect of respiratory muscle strength and endurance after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals

Secondary

MeasureTime frame
It is expected to find the electromyographic activity of the accessory muscle of inspiration in the evaluation of inspiratory muscle strength and inspiratory muscle resistance after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals;It is expected to find the palmar pressure force after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals;It is expected to find the electromyographic activity of the finger flexor muscles after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals;It is expected to correlate the muscle strength of the finger flexor muscles with the strength of the accessory muscles of inspiration after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals ;It is expected to correlate the electromyographic activity of the finger flexor muscles with the electromyographic activity of the accessory muscles of inspiration after Transcranial Direct Current Stimulation of the motor area bilaterally in healthy young and elderly individuals

Countries

Brazil

Contacts

Public ContactGuilherme Arêas

Faculdade de Educação Física e Fisioterapia

guilhermemepta@ufam.edu.br+55(92)99356-0935

Outcome results

None listed

Source: REBEC (via WHO ICTRP)