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Erva-mate influence on iron absorption from the diet in people with hereditary iron overload

Effect of erva-mate (ilex paraguariensis st. hil.) on the absorption of iron in patients with hereditary hemochromatosis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5nrrwc
Enrollment
Unknown
Registered
2018-10-30
Start date
2017-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

disorders of iron metabolism

Interventions

All participants will receive all treatments: Ilex paraguariensis infusion, water and silybum marianum suspension and in random order. This is a crossover study and will be with 12 participants. Inte
Genetics
Dietary supplement
Other
SP6.051.227

Sponsors

Universidade Federal de Santa Catarina
Lead Sponsor
Centro de Hematologia e Hemoterapia de Santa Catarina - HEMOSC
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: hereditary hemochromatosis; live in Florianópolis, State of Santa Catarina Brazil; a minimum age limit of 18 years; maintenance treatment; homozygous for the C282Y mutation in HFE; absence of anemia and a minimum interval of one month from the last phlebotomy.

Exclusion criteria

Exclusion criteria: Use of chelating agents 24 hours prior to the start of the study; presence of acute or chronic infections; cancer; diagnosis for secondary hemochromatosis and in women in the menstrual phase of the menstrual cycle.

Design outcomes

Primary

MeasureTime frame
The appearence and clearence of total serum iron will be assessed by calculating the area under the serum iron curve over the 4 hours observation period. The area under the serum iron curve will be calculated using the trapezium rule by the statistic software GraphPad Prism 6.0 The area under the curve is constructed with the results for the concentration of serum iron in micromol per liter as a function of the time in hours. Samples of blood collected at time zero and after 1, 2, 3 and 4 hours. The expected result is to demonstrate whether the consumption of Ilex paraguariensis (erva mate) can decrease the absorption of iron meal in patients with hereditary hemochromatosis. Thus, to contribute with perspectives related to the adjuvant treatment of hereditary hemochromatosis, with the search for natural chelating compounds, which may reduce the absorption of dietary iron in the patients.—

Secondary

MeasureTime frame
Secondary outcomes are not expected.—

Countries

Brazil

Contacts

Public ContactCristiane Pagliosa

Universidade Federal de Santa Catarina

mcristiane@gmail.com+55 48 996020653

Outcome results

None listed

Source: REBEC (via WHO ICTRP)