Comparison between blood types in the body and their influence on bone regeneration

Comparative evaluation of pCO2, pO2, tCO2, O2 saturation, ionized calcium, pH, lactate, and magnesium concentrations between mandibular medullary blood, peripheral blood, and iliac medullary blood

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

REBEC

Registry ID

RBR-5mwjh3z

Enrollment

Registered

2026-07-04

Start date

2025-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Chemical Analysis

Interventions

This is a non-randomized, uncontrolled, open-label (non-blinded) observational clinical study. Participants, candidates for dental implant surgery requiring bone grafting, underwent blood sampling fro

Eligibility

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients aged 40 to 70 years; both sexes; without associated comorbidities; candidates for dental implant surgery; requiring total reconstruction of the upper alveolar ridge; requiring the placement of 1 to 2 implants in the posterior region of the mandible with bone grafting in the maxilla

Exclusion criteria

Exclusion criteria: Pregnant and breastfeeding patients without complete postoperative follow-up; with a history of neoplastic diseases treated with radiotherapy or chemotherapy; active smokers, or those allergic to the biomaterials used in the research

Design outcomes

Primary

Measure	Time frame
Expected outcome: To evaluate the different biochemical compositions of PO2 concentration; TCO2, SatO2, ionized calcium, pH, and lactate and magnesium in peripheral blood, mandibular medullary blood, and iliac medullary blood.;Outcome found: the anatomical origin of the blood sample significantly influences gasometric parameters such as pH, PCO2, PO2, HCO3? and oxygen saturation (SatO2), which showed statistically relevant variations between peripheral blood, mandibular medullary blood and iliac medullary blood.	—

Measure

Time frame

Expected outcome: To evaluate the different biochemical compositions of PO2 concentration; TCO2, SatO2, ionized calcium, pH, and lactate and magnesium in peripheral blood, mandibular medullary blood, and iliac medullary blood.;Outcome found: the anatomical origin of the blood sample significantly influences gasometric parameters such as pH, PCO2, PO2, HCO3? and oxygen saturation (SatO2), which showed statistically relevant variations between peripheral blood, mandibular medullary blood and iliac medullary blood.

—

Secondary

Measure	Time frame
No secondary outcomes were expected.	—

Countries

Contacts

Public ContactWilliam de Mattos

Centro de Pesquisas Odontologicas São Leopoldo Mandic SS

claudio.jodas@slmandic.edu.br+55-019-32113600

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026