Changes in DNA (epigenetics) and in the behavioral, emotional and conscience aspects of women with painful Temporomandibular Disorders before and after a Mindfulness program

Differentiation in global dna methillation, snp polymorphisms and cognitive-behavior-emotional involvement of women with chronic painful Tmd before and after Mindfulness intervention

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-5mvjqt

Enrollment

Unknown

Registered

2020-10-04

Start date

2020-03-09

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporomandibular Joint Dysfunction Syndrome

Interventions

Mindfulness-based intervention. Mindfulness program of 8 weeks, with 8 weekly meetings lasting 2 hours each and an extra 4 hour meeting (called immersion), totaling 9 meetings. Group with 23 participa

Behavioural

Other

F02.463.551

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Volunteer women; age between 18 and 45 years; diagnosis of painful TMD for more than 3 months.

Exclusion criteria

Exclusion criteria: Volunteers undergoing any type of treatment for painful Temporomandibular Dysfunction; previous history of tumors; previous history of trauma or head and neck surgery; presence of neurological disorders; presence of psychiatric disorders; volunteers who use controlled medications, such as anxiolytics, antidepressants and anticonvulsants; pregnant volunteers.

Design outcomes

Primary

Measure	Time frame
Painful reduction resulting from chronic painful Temporomandibular Disorder,immediately after the end of the intervention, as well as epigenetic changes. Pain reduction will be assessed by quantitative sensory tests such as the pressure pain threshold and hyperalgesia (using a digital algometer) and allodynia (using a rotating electric toothbrush, with a 5-second stimulation). The three tests will be applied at the same pre points -determined). The epigenetic analysis will be performed by global DNA methylation and by methylation analysis of single nucleotide polymorphisms (SNPs), previously identified related to chronic painful temporomandibular disorder.	—

Measure

Time frame

Painful reduction resulting from chronic painful Temporomandibular Disorder,immediately after the end of the intervention, as well as epigenetic changes. Pain reduction will be assessed by quantitative sensory tests such as the pressure pain threshold and hyperalgesia (using a digital algometer) and allodynia (using a rotating electric toothbrush, with a 5-second stimulation). The three tests will be applied at the same pre points -determined). The epigenetic analysis will be performed by global DNA methylation and by methylation analysis of single nucleotide polymorphisms (SNPs), previously identified related to chronic painful temporomandibular disorder.

—

Secondary

Measure	Time frame
Cognitive-behavioral-emotional changes, measured by validated, self-applicable and specific protocols. They will be evaluated immediately after completion of the intervention.	—

Countries

Brazil

Contacts

Public ContactChristie Leite-Panisse

Universidade de São Paulo-Faculdade de Filosofia Ciências e Letras de Ribeirão Preto

christie@usp.br+55(16)3315 4124

Outcome results

None listed

Source: REBEC (via WHO ICTRP)