Subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution in open bariatric surgery: randomized controlled trial.

Intraoperative subcutaneous irrigation with 2% aqueous chlorhexidine vs. 0.9% saline solution and surgical wound infection rate in open bariatric bypass surgery: a prospective randomized controlled trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-5mcym7y

Enrollment

200

Registered

2026-02-27

Start date

2025-03-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical Wound Infection

Interventions

This is a randomized, controlled, two-arm, single-blind clinical study. A total of 148 patients were included. 71 patients were randomized to the 2% aqueous chlorhexidine intervention group and 77 pat

Eligibility

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Paciente who have undergone open bariatric bypass surgery; patients >= 18 years old and <=65 years old; both sexes (female and male)

Exclusion criteria

Exclusion criteria: Patients allergic to chlorhexidine; videolaparoscopic bariatric surgery; sleeve gastrectomy

Design outcomes

Primary

Measure	Time frame
Our primary outcome was the surgical wound infection rate, and we expected to find a decrease with the use of 2% aqueous chlorhexidine. However, similar rates of surgical wound infection were observed in both groups. 22 patients presented with superficial surgical wound infection in the chlorhexidine group (30.9%) and 19 patients presented with surgical wound infection in the saline group (24.7%), with only one infection classified as deep, requiring surgical intervention in this group. Based on Pearson's chi-square test, no statistically significant difference was observed between the groups, with a p-value of 0.501.	—

Measure

Time frame

Our primary outcome was the surgical wound infection rate, and we expected to find a decrease with the use of 2% aqueous chlorhexidine. However, similar rates of surgical wound infection were observed in both groups. 22 patients presented with superficial surgical wound infection in the chlorhexidine group (30.9%) and 19 patients presented with surgical wound infection in the saline group (24.7%), with only one infection classified as deep, requiring surgical intervention in this group. Based on Pearson's chi-square test, no statistically significant difference was observed between the groups, with a p-value of 0.501.

—

Secondary

Measure	Time frame
No secondary outcomes are expected	—

Countries

Brazil

Contacts

Public ContactOdair Neto

Hospital Santa Casa de Curitiba

drodair.neto@gmail.com+55(44)998145880

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 14, 2026