Type 2 Diabetes Mellitus
Conditions
Interventions
This is a non-randomized longitudinal clinical study. Individuals of both sexes, any ethnicity, aged between 30 and 65 years old, and with a minimum of 15 teeth were invited to participate in this stu
Type_2_Diabetes_Mellitus_well_ Control+Periodontitis (n=32)
Type_2_Diabetes_Mellitus_without_Periodontitis (n=32)
Periodontitis (n=31)
and Control (n=32). Their glycemic, lipid, and periodontais profiles were examined before and after (45, 90, and 180 days) periodontal treatment. Patients in the Periodontitis and Type_2_Diabetes_Mell
E04.545
Sponsors
Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara
Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara
Eligibility
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals aged between 30 and 70 years were included. For this sample, individuals of both sexes were selected. They should have at least 15 teeth in the oral cavity and could be from any ethnic-racial group. For the group with type 2 diabetes mellitus, participants would have the diagnosis confirmed by the attending physician
Exclusion criteria
Exclusion criteria: Individuals with a history of hepatitis and Human Immunodeficiency Virus infection (HIV), anemia, antibiotic pre-medication in the last 6 months, or chronic use of anti-inflammatory drugs were excluded, as well as pregnant or lactating research participants. Regarding type 2 diabetes mellitus, prediabetic individuals and research participants with type 2 diabetes mellitus using thiazolidinedione medications such as rosiglitazone, pioglitazone, and roglitazone were also excluded, as these activate natural Peroxisome Proliferator Activated Receptor Gamma (PPARG)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in periodontal clinical parameters and biochemical parameters is expected after 90 and 180 days following the completion of periodontal treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to assess the effect that periodontal treatment had on the gene and protein expression of molecules related to the immune system and glycemic, lipid, and oxidative metabolism | — |
Countries
Brazil
Contacts
Public ContactRaquel Scarel-Caminaga
Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquara
Outcome results
None listed