Shock Septic Sepsis
Conditions
Interventions
This is a two-arm, double-blind, randomized controlled clinical trial to be conducted in an adult intensive care unit with patients diagnosed with sepsis or septic shock. Patients will be allocated to
Sponsors
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP)
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Both sexes; Over 18 years of age; Diagnosis of sepsis or septic shock according to the criteria defined by the American Society of Critical Care Conference, according to the Sequencial Organ Failure Assessment (SOFA) tool
Exclusion criteria
Exclusion criteria: Those who do not meet the inclusion criteria; Patients with coagulopathies; Severe neurological diseases; Prior use of photobiomodulation therapies; Individuals with extensive lesions or infections in the application area
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| An improvement in peripheral oxygenation is expected in patients with sepsis or septic shock, verified by pulse oximetry, based on the observation of variations in pre- and post-intervention measurements after seven days of application of transcutaneous photobiomodulation over the radial artery | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the reduction of serum concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a) after transcutaneous photobiomodulation, analyzed through laboratory tests;To assess the effect of transcutaneous photobiomodulation on stabilizing the hemodynamic parameters of patients with sepsis or septic shock during the follow-up period, analyzed through patient monitoring;Assess the reduction of serum lactate levels after applying transcutaneous photobiomodulation, analyzed through routine laboratory tests;Assess the evolution of the Sequential Organ Failure Assessment (SOFA) score after the intervention, checking for possible reduction in organ dysfunction, analyzed daily score assessment;Assess the changes in body electrical impedance through bioimpedance after applying transcutaneous photobiomodulation, analyzed using the InbodyS10 equipment;Evaluate the changes in skin microcirculation at the site of transcutaneous photobiomodulation application after the intervention, analyzed using a laser doppler;To assess the changes in skin temperature in the area where transcutaneous photobiomodulation is applied during the follow-up period, analyzed using a thermal imaging camera | — |
Countries
BR
Contacts
Public ContactGabrielli Zavatieri
Hospital das clínicas da Faculdade de medicina de Ribeirão Preto
Outcome results
None listed