spine tuberculosis
Conditions
Interventions
A group of 130 patients will be submitted to analysis of the data from their medical records, from the period of entry into the service up to 6 months after the outpatient follow-up. The requested dat
Other
Z00.0
Sponsors
Irmandade da Santa Casa de Misericórida de São Paulo
Irmandade da Santa Casa de Misericórida de São Paulo
Eligibility
Age
1 Days to 100 Years
Inclusion criteria
Inclusion criteria: Both genders; age: 1 day of life up to 100 years; diagnosis of tuberculosis of the spine. Diagnosis will be defined by: isolation of the etiological agent or by clinical and radiographic criteria characteristic of tuberculosis vertebral involvement and or pathological examination compatible with tuberculosis and / or positive therapeutic test. Isolation of the agent will be considered the presence of BAAR by the Ziehl-Neelsen method, molecular rapid test (real-time PCR) and culture for mycobacteria. The radiographic findings are visualized in radiographs of the spine according to the affected level, in the posteroanterior and profile incidences, with the following findings: aneurysmal abscess, sacral lesions, disc space reduction, vertebral collapse, kyphosis, calcification. The findings found on computed tomography are a decrease in the height of the vertebral body, osteolysis in the terminal plates of the vertebral bodies adjacent to the disc, pre-vertebral abscess, paravertebral abscess. Magnetic resonance imaging findings are hyposignal of the affected disc in weighted images at t1; hypersignal of the disc and the vertebral plateaus adjacent to the disc in t2-weighted images; epidural involvement; paraespinal abscess with a smooth abscess wall. Clinical Criteria: Indolent chronic infection associated with leukocytosis and changes in inflammatory tests, CRP and HSV, associated or not with the positive tuberculin test; Anatomopathological examination: The presence of epithelioid macrophage proliferation constituting confluent granulomas with presence of giant Langerhans cells with central foci of caseous necrosis and surrounding lymphocytic infiltrate was considered a characteristic of TB, with positive BAAR using the Ziehl-Neelsen method . The samples were submitted to routine methods for optical microscopy: 10% formaldehyde fixation, paraffin blocks cut into a 3 micron thick microtome and stained by hematoxylin-eosin (HE), Grocott (for fungi research) and Ziehl-Neelsen (for the BAAR survey). The biopsies were processed according to routine of the laboratory of Pathological Anatomy;
Exclusion criteria
Exclusion criteria: Do not meet the criteria for definition of tuberculo spondylodiscites case; incomplete Medical Record; incomplete image checks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify clinical and epidemiological characteristics that contribute to the diagnosis and treatment of tuberculous spondylodiscitis. Identify the region of the spine of most frequent involvement. To describe clinical features that contribute to the diagnosis and treatment of patients with tuberculous spondylodiscitis such as: weight loss, signs and symptoms such as fever, night sweats, increased inflammatory tests such as HSV and CRP, hematometric changes in the complete blood count, pain and presence of neurological deficits as well as to classify the severity of neurological impairment through the Frankel scale. The data obtained will be submitted to statistical evaluation using SPSS version 13.0 for Windows. For the descriptive analysis, the qualitative variables will be described in frequencies (number and percentages). The quantitative, with summary measures (mean, median, standard deviation, minimum and maximum). For qualitative versus qualitative inferences, the chi-square test will be used. For qualitative versus quantitative inferences, Student's t (parametric) or Mann-Whitney (non-parametric) tests were used, using 5% for level of significance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactIgor Zanon
Irmandade da Santa Casa de Misericórida de São Paulo
Outcome results
None listed