Hypertension
Conditions
Interventions
50 hypertensive patients of both sexes, aged 45 to 65 years, will be randomized into two groups: magnesium group and placebo group. Patients will be instructed to ingest the capsules at two times of t
Dietary supplement
Sponsors
Hospital Universitário Pedro Ernesto
Universidade do Estado do Rio de Janeiro - UERJ
Eligibility
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Outpatient patients between the ages of 40 and 65 years. Both genders, with postmenopausal women. Hypertensive patients with systolic blood pressure greater than or equal to 140 mmHg and / or diastolic blood pressure greater than or equal to 90 mmHg. In pharmacological treatment, with stable use of at least two antihypertensive classes in the last four weeks. Patient with body mass index less than or equal to 35 kg / m2. Patients with habitual food consumption maintained for at least four weeks. Signature of the Informed Consent Term (SICT).
Exclusion criteria
Exclusion criteria: Smoking. Diabetes Mellitus. Hormone replacement therapy. Hypertension with blood pressure greater than 160/100 mmHg. Use of beta-blocker or statin. Evidence of secondary hypertension. Changes in thyroid function, chronic renal and liver diseases. Clinically evident coronary disease with prior history of acute myocardial infarction and / or myocardial revascularization, with clinical signs of heart failure, symptomatic cardiac arrhythmia, or clinically significant valve disease, prior cerebrovascular accident. Use of nutritional supplements (vitamins, minerals) for up to seven days before the start of the study. Patients presenting with any serious illness and any condition, illness or therapy that, in the opinion of the investigator, may impair the results, interfere with the study objectives or jeopardize patient safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcomes to evaluate arterial stiffness: - Pulse wave velocity by the Complior method (gold standard). Check if there was a reduction of the basal value considering a p <0.05.;Outcomes to evaluate endothelial function: - Average of the peak after occlusion by the Pericam method. Check if there was an increase in baseline value considering a p <0.05. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure by the oscillometric method and ambulatory blood pressure monitoring. Check if there was a reduction of the basal value considering a p <0.05.;C-reactive protein ultra-sensitive by blood test. Check if there was a reduction of the basal value considering a p <0.05. ;Urinary magnesium by the method of collection of urine of 24h. Check if there was an increase in baseline value, considering a p <0.05 in the magnesium supplemented group. | — |
Countries
Brazil
Contacts
Public ContactFaculdade de Ciências Médicas FCM
Faculdade de Ciências Médicas
Outcome results
None listed