Gingivitis
Conditions
Interventions
This is a randomized, parallel, double-blind controlled clinical trial. Control group: 35 participants with gingivitis using a flavored water-based mouthwash
Positive control group: 35 participants with gingivitis using a mouthwash containing 0.12% chlorhexidine digluconate
Experimental group: 35 participants with gingivitis using a mouthwash containing a dispersion of Surface Pre-Reacted Glass-ionomer nanoparticles. The test and control mouthwashes will be provided to p
Sponsors
Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista
Instituto de Ciência e Tecnologia - São José dos Campos - Universidade Estadual Paulista
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Individuals with gingivitis presenting a gingival bleeding index equal to or greater than 10%; probing depth equal to or less than 3 mm; aged 18 years or older; in good general health; and willing to participate in the study by signing the informed consent form
Exclusion criteria
Exclusion criteria: Individuals with periodontitis; smokers; pregnant or breastfeeding women; individuals who have used mouthwashes within the past 6 months; those under chronic use of medications that affect periodontal response, such as antibiotics, anti-inflammatory drugs, anticonvulsants, immunosuppressants, or sodium channel blockers within the past 6 months; individuals with systemic conditions such as diabetes, cardiovascular disease, cancer, obesity, rheumatoid arthritis, metabolic syndromes, respiratory diseases, or those requiring antibiotic prophylaxis; and individuals wearing orthodontic appliances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the reduction of gingival bleeding, determined by probing, through comparison between the groups at baseline and at the end of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| A reduction in the plaque index, a decrease in microorganisms in the dental plaque samples, and lower cytokine levels in the gingival crevicular fluid are expected to be observed at baseline and at the end of the study | — |
Countries
Brazil
Contacts
Public ContactAndréa De Marco
Instituto de Ciência e Tecnologia de São José dos Campos - UNESP
Outcome results
None listed