Relationship between IOP reduction and ocular blood perfusion

Effect of IOP reduction on peripapillary vascular density in eyes with optic disc drusen - IOP: Intraocular Pressure IOP: Intraocular Pressure

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-5hjbmtx

Enrollment

Unknown

Registered

2022-06-24

Start date

2021-08-01

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic Dosc

Interventions

Experimental group: 15 eyes using Latanoprost eye drops at 50mcg/mL (micrograms/milliliter) 1 drop once a day for 6 months. Control Group: 15 eyes without using eye drops for 6 months. During 6 months

density of optic disc nerve fibers through OCT (Optical Coherence Tomography)

visual field through campimetry

and intraocular pressure through applanation tonometry

D26.776.708.645

Eligibility

Inclusion criteria

Inclusion criteria: Patients with optic disc drusen without a history of treatment with hypotensive eye drops; patients older than 18 years; absence of macular diseases; absence of vascular optic diseases; axial diameter less than 25mm; open camerular angle on gonioscopic examination

Exclusion criteria

Exclusion criteria: Patients with optic disc drusen who have already used hypotensive eye drops; patients under 18 years of age; presence of any maculopathy or vascular optic disease; axial diameter greater than 25mm; closed camerular angle on gonioscopic examination

Design outcomes

Primary

Measure	Time frame
Is expected increase in peripapillary vascular density by at least 5%	—

Secondary

Measure	Time frame
Is expected reduction of intraocular pressure by 30% of the initial value	—

Countries

Brazil

Contacts

Public ContactComitê de Ética em Pesquisa

Hospital Oftalmológico de Brasília

cephob@hobr.com.br+556134424136

Outcome results

None listed

Source: REBEC (via WHO ICTRP)