Cannabidiol
Conditions
Interventions
This is a randomized, double-blind, crossover, within-person study. Data from previous studies with similar outcome assessment methodology to this study were used to calculate the sample size. The sam
V03.175.250.500.500
Sponsors
Faculdade de Odontologia da Universidade de São Paulo - FOUSP
Faculdade de Odontologia da Universidade de São Paulo - FOUSP
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Healthy participants without systemic involvement; of both genders; aged between 18 and 40 years; who required extraction of bilaterally impacted lower third molars diagnosed by orthopantomograms; Teeth with similar bilateral bone impactions, assessed by panoramic radiography, presenting the same dental impaction classification (IIB) according to Pell and Gregory (1933) and Winter (1926)
Exclusion criteria
Exclusion criteria: Research participants who used analgesics or anti-inflammatories in the 48 hours prior to tooth extractions; research participants with sensory-sensory alterations; research participants who are pregnant or lactating, or who present a positive rapid pregnancy test (to be performed on the day of the procedure); research participants with any history of hypersensitivity reactions to any of the medications that will be used in the study: mepivacaine, amoxicillin, ibuprofen, dipyrone, chlorhexidine, and cannabidiol; research participants who test positive at the time of surgery for previous use of Cannabis sativa (Test to be performed on the day of the procedure); research participants who present an infection or postoperative alveolith; research participants who do not follow postoperative recommendations; research participants who do not attend follow-up appointments; when the surgical time exceeds 60 minutes; when technical failure in anesthesia occurs or when the use of more than 3 anesthetic tubes is necessary; research participants who use any medication with analgesic and/or anti-inflammatory action in the postoperative period, in addition to those prescribed in the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: To evaluate the use of Cannabidiol as a strategy for preemptive analgesia | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome: It is expected a reduction of preoperative anxiety | — |
Countries
Brazil
Contacts
Public ContactBergson de Moraes
Faculdade de Odontologia da Universidade de São Paulo - FOUSP
Outcome results
None listed