Laser effect in the treatment of mouth wounds caused by the treatment of head and neck cancer

Conditions

Convalescence after radiotherapy, oral mucositis, head and neck cancer

Martins AFL, Morais MO, de Sousa-Neto SS, de Jesus APG, Nogueira TE, Valadares MC, Freitas NMA, Batista AC, Leles CR, Mendonça EF.

2020-10-2817 citations

10.1007/s10103-020-03167-z

Cost-effectiveness randomized clinical trial on the effect of photobiomodulation therapy for prevention of radiotherapy-induced severe oral mucositis in a Brazilian cancer hospital setting.

Lopes Martins AF, Nogueira TE, Morais MO, de Sousa-Neto SS, Oton-Leite AF, Valadares MC, Aires Freitas NM, Leles CR, Mendonça EF.

2020-07-0312 citations

10.1007/s00520-020-05607-6

Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial

Allisson Filipe Lopes Martins, Túlio Eduardo Nogueira, Marília Oliveira Morais, Angélica Ferreira Oton‐Leite, Marize Campos Valadares et al. (9 authors)

Trials2019-02-0132 citations

10.1186/s13063-019-3196-8

Interventions

Experimental group: Patients in this group (n = 25) will undergo laser therapy five times a week (from Monday to Friday) during radiotherapy treatment. The application of the laser will begin in the f

Ingestion of 1.5 liters of water and maintenance of good oral hygiene. In case of wounds, oral ointment based on hydrocortisone 5mg, neomycin 5mg, troxerrutin 20mg, ascorbic acid 0.5mg, benzocaine 2mg

Device

Radiation

E02.594.540

Eligibility

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Volunteers with more than 18 years. Both sexes. Toothed or edentulous. With cancer of the head and neck that will undergo radiotherapy (minimum dose of 50Gy) and chemotherapy

Exclusion criteria

Exclusion criteria: Volunteers with tumors of salivary glands or Sjogren's syndrome. Patients previously submitted to radiotherapy in the head and neck region or chemotherapy. Patients with lymphoma. Patients with melanoma. Patients with skin cancer.

Design outcomes

Primary

Measure	Time frame
Lower cost due to severe levels of oral mucositis (Degrees III and IV of the World Health Organization scale) the experimental group evaluated by appropriate statistical tests according to With the distribution of the data. Costs will be calculated with opioid medications, use of probes, hospitalizations and parenteral nutrition.;Lower levels per deciliter of saliva in the mediators of inflammation evaluated by flow cytometry in the experimental group evaluated by appropriate statistical tests according to With the distribution of the data.	—

Measure

Time frame

Lower cost due to severe levels of oral mucositis (Degrees III and IV of the World Health Organization scale) the experimental group evaluated by appropriate statistical tests according to With the distribution of the data. Costs will be calculated with opioid medications, use of probes, hospitalizations and parenteral nutrition.;Lower levels per deciliter of saliva in the mediators of inflammation evaluated by flow cytometry in the experimental group evaluated by appropriate statistical tests according to With the distribution of the data.

—

Secondary

Measure	Time frame
Radiotherapy interventions	—

Countries

Brazil

Contacts

Public ContactAllisson Filipe Martins

Hospital Araújo Jorge - Associação de Combate ao Cancer em Goias

allissonfilipe@hotmail.com+55 62 38787463

Outcome results

None listed