Cardiovascular physiological phenomena
Conditions
Interventions
This study is a randomized, double-blind, crossover clinical trial that will include nineteen healthy adult participants, with each participant serving as their own control. The study will be conducte
Sponsors
Universidade Federal de Santa Catarina
Universidade Federal de Santa Catarina
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Adults; of both sexes; aged between 18 and 40 years, will be included
Exclusion criteria
Exclusion criteria: Participants will be excluded if they have a history of chronic diseases; are smokers; use medications on a continuous basis that may influence vascular responses; have a known allergy to Passiflora incarnata or to any component of the formulation; use drugs with sedative effects, such as pentobarbital and hexobarbital; anticoagulants such as warfarin; or monoamine oxidase inhibitors (MAOIs), including isocarboxazid, phenelzine, and tranylcypromine, due to their potential to interfere with the hemodynamic responses assessed and to increase the risks involved in the study. In addition, participants who regularly use antioxidant supplements or nitrates, or who have consumed polyphenol-rich foods (e.g., beetroot, chocolate, green tea, citrus fruits) within the 24 hours preceding the experiment will also be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelial function is expected to be assessed via flow-mediated dilation, with an anticipated increase in endothelium-dependent vasodilatory response of the brachial artery in the Passiflora group | — |
Secondary
| Measure | Time frame |
|---|---|
| A significant reduction in blood pressure and heart rate is expected in the Passiflora group | — |
Countries
Brazil
Contacts
Public ContactWelliton Oracz
Universidade Federal de Santa Catarina
Outcome results
None listed