Other acute pancreatitis
Conditions
Interventions
Patients will be randomized into 3 groups, namely: 1) infusion of 0.9% saline solution 100mL with indomethacin 100mg IV, in a single dose, immediately before the procedure (284 patients)
2) administration of 100mg indomethacin via the rectum, in a single dose, immediately before the procedure (284 patients)
and 3) infusion of only 0.9% saline solution 100mL IV, in a single dose, immediately before the procedure. (284 patients). Medications will be administered by the anesthesiologist. The randomization w
E02.319
Sponsors
Serviço de Neurorradiologia do Hospital São José do Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre
Universidade Federal de Ciências da Saúde de Porto Alegre
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years of age, who are referred to the Neuroradiology Service of Hospital São José do Complex Santa Casa de Misericórdia of Porto Alegre to perform ERCP who, after due explanations about the study, agree to participate and sign the informed consent form (IC)
Exclusion criteria
Exclusion criteria: Patients with allergy to indomethacin, previous digestive bleeding or a history of peptic ulcer disease, chronic renal failure, biliary prosthesis or previous papillotomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the incidence of post-procedure acute pancreatitis, seen from the presence of abdominal pain in the first 48 hours post-procedure associated with an increase in amylase or lipase in the range of 3 times or more from the upper limit of normality, evaluation in absolute percentage comparing intervention and control groups | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected | — |
Countries
Brazil
Contacts
Public ContactJúlio Pereira Lima
Outcome results
None listed