Evaluation of Pregabalin as preemptive analgesia in postoperative pain in orthopedic foot and ankle surgery: randomized clinical trial

Use of Pregabalin as preemptive analgesia in orthopedic foot and ankle surgery

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

REBEC

Registry ID

RBR-5g6rk3h

Enrollment

Unknown

Registered

2025-09-22

Start date

2025-09-30

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pain

Interventions

This is a randomized, double-blind clinical trial. The sample will consist of 60 participants over 18 years of age, divided into two arms of 30 participants each. Participants were seen and monitored

E03.091

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with surgical indications; originating from elective and emergency orthopedic clinics at Santa Casa de Misericórdia de Maceió; over 18 years of age; of both sexes

Exclusion criteria

Exclusion criteria: Patients with neuropathy of any etiology; history of abusive use or addiction to analgesics and opioids; history of allergy or intolerance to the use of Pregabalin; history of chronic use of Pregabalin

Design outcomes

Primary

Measure	Time frame
Expected outcome: It is expected that there will be a reduction in postoperative pain in patients who used Pregabalin preemptively, 2 hours before the surgical procedure	—

Secondary

Measure	Time frame
Expected outcome: It is expected that with the reduction in the use of analgesics and opioids, there will be a decrease in undesirable effects such as nausea and vomiting in the group using Pregabalin	—

Countries

Brazil

Contacts

Public ContactAntonio Alicio de Oliveira Junior

Centro Universitário CESMAC

aliciooliveira@uol.com.br+55(82)4009-6001

Outcome results

None listed

Source: REBEC (via WHO ICTRP)