Muscular Dystrophies
Conditions
Interventions
This is a two-arm, double-blind, randomized controlled clinical trial. Experimental group: 16 elderly people who received supplementation with gamma-aminobutyric acid, 100mg in capsules, daily, for 16
Sponsors
Universidade Federal de Ouro Preto
Universidade Federal de Ouro Preto
Eligibility
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 60 years or older; residents in the cities of Mariana and/or Ouro Preto; present at least pre-sarcopenia level; are vaccinated against Covid-19; commit to receiving the physical education professional assigned to do the training in their homes; maintain a regular frequency of at least 80% of training sessions
Exclusion criteria
Exclusion criteria: Not being in the situation described in the inclusion criteria; refuse to sign the TCLE; not completely responding to the research instrument; not showing interest in participating in the intervention; have any food allergies to GABA supplementation; food allergy to rice germ and gelatin; present severe cardiovascular alterations; present severe renal alterations; have dementia; present Parkinson's disease; present severe neuropsychological alterations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1: Evaluate the effect of the association of home physical training with GABA supplementation on physical parameters and on the improvement of sleep quality in the elderly;Outcome found 1: It was observed that 91.6% of the volunteers were no longer considered sarcopenic, according to the parameters for the diagnosis of sarcopenia defined by the EWGSOP2, after supplementation with GABA and a home exercise program. On the other hand, 41.7% of the volunteers who took placebo and did physical exercises at home remained sarcopenic, using the same sarcopenia evaluation criteria. It was also observed that in the PSQI, a questionnaire that assesses the quality of sleep, there was a marked reduction in the overall PSQI score, as well as in the Latency and Sleep Disturbance domains in the GABA Group. This reduction had a significant difference in the GABA Group compared to the Placebo Group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected Outcome 2:To verify the effect of home physical training associated with GABA supplementation on levels of muscle strength, lean mass and functional capacity;Outcome found 2: It was observed that the home physical training performed was efficient to increase the levels of all physical and functional parameters tested, after 16 weeks of training, regardless of GABA supplementation. | — |
Countries
Brazil
Contacts
Public ContactLenice Becker
Universidade Federal de Ouro Preto
Outcome results
None listed