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Effects of using Colchicine for the prevention of inflammatory complications, arrhythmias and pain control in the postoperative period of cardiac surgery.

Effects of Colchicine in the prevention of Post-pericardiotomy syndrome, pain control and occurrence of Atrial Fibrillation in the postoperative period of Cardiac Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5f426rx
Enrollment
Unknown
Registered
2022-07-06
Start date
2020-07-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Interventions

Total 60 patients were recruited for the study. The randomization of the sample was performed to allocate the subjects in the group submitted to the use of placebo (placebo group) and in the group sub
D03.132.225

Sponsors

Universidade de Santa Cruz do Sul
Lead Sponsor
Universidade de Santa Cruz do Sul
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients in post operative of cardiac surgery; both sexes; age 18 to 85 years.

Exclusion criteria

Exclusion criteria: Patients undergoing emergency cardiac surgery; presence of atrial fibrillation in the preoperative period; use of pacemakers; patients with chronic renal failure; patients undergoing treatment for endocarditis.

Design outcomes

Primary

MeasureTime frame
Colchicine did not alter the occurrence of post-pericardiotomy syndrome and had a small effect size (greater than 0.02) on pain control, assessed using the Visual Analog Pain Scale (VAS), which is an instrument self-report, consisting of colors and facial expressions in which the degree of pain varies from zero to ten, with zero meaning total absence of pain and ten, the level of maximum bearable pain.—

Secondary

MeasureTime frame
51% improvement in C-reactive protein indices in patients who used Colchicine in the postoperative period of cardiac surgery, evaluated through blood sample considering reference value less than 0.6 mg/dL for the presence of inflammation considering the present values in the post-intervention and in the immediate postoperative period.—

Countries

Brazil

Contacts

Public ContactBárbara Tabach

Universidade de Santa Cruz do Sul

barbaraswa@hotmail.com+55(51)985185421

Outcome results

None listed

Source: REBEC (via WHO ICTRP)