Coronavirus Infections
Conditions
Interventions
The activities will start after signing the informed consent form approved by the Research Ethics Committee. All care for the safety of the participants and the work team will be taken. First, an eval
and the physical training groups randomly divided according to the association of training (T) and recovery (R) with hypoxia (H) or normoxia (N): a) TH + RH, b) TN + RH, c) TN + RN. Each group will ha
Other
Sponsors
Escola de Educação Física e Esporte de Ribeirão Preto
Faculdade de Ciências Farmacêuticas de Ribeirão Preto
Projeto USP Vida - Fundação da Universidade de São Paulo (FUSP)
Eligibility
Age
30 Years to 69 Years
Inclusion criteria
Inclusion criteria: Participants women and men aged between 30 and 69 years convalescent from COVID-19 (having the test with a positive diagnosis); having moderate to severe symptoms; approximately 30 days since recovery from clinical signs or medical discharge (if you have been hospitalized); have previous experience in aerobic physical activity.
Exclusion criteria
Exclusion criteria: Exposure to high places (altitude greater than 1500 m) in the last three months; significant physical limitations to carry out evaluations and intervention; acute or chronic clinical illnesses without medical supervision; anemia; use of immunosuppressive drugs; pregnant women; hormone replacement; smokers; excessive use of alcohol or drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvements in maximum aerobic power (VO2max) and anaerobic threshold (AT) An incremental test will be used to estimate AT, VO2max, and iVO2max. The warm-up will be 5 min in cycle ergometer (E200, COSMED, Italy) without load (0 Kp). At each 2-minute stage, there will be an increase of 0.25 Kp (approximately 13 W) until voluntary exhaustion27. O2 consumption will be measured with each breath, using the gas analyzer (Quark - PFT®, COSMED, Italy), which will be calibrated according to the manufacturer's specifications. Blood samples (25 ?L) will be collected from the earlobe at each stage's end to analyze the blood [La-]. Concomitantly, HR and PSE will be monitored at the end of each stage. VO2max will be defined as the highest mean VO2 in the last 60 s in the test, considering at least three of the criteria: volitional exhaustion, blood [La-] ? 8.0 mmol,> 90% of the maximum HR predicted for age (HRmax = 220 - age), PSE ? 9, respiratory quotient ? 1.10, inability to maintain a frequency of at least 60 rpm. The iVO2max will be the lowest intensity at which the individual reaches VO2max during the test. If the individual doesn't sustain the intensity until the stage's end, the iVO2max will be assumed like peak power (PP), estimated by equation. A partial evaluation containing the incremental test will be carried out at week 5 (half of the intervention) to adjust the training load (evaluation 2). Therefore, the incremental test will be performed in four moments: evaluation 1 (week 0 - pre), evaluation 2 (week 5 - half of the intervention), evaluation 3 (week 9 - post), and evaluation 4 (week 13 - four after the end) intervention). ;Improvements in body composition For the analysis of body composition and the distribution of lean, bone, and adipose tissue, the dual-energy X-ray absorptiometry technique (iDXA - GE Lunar - DPX-NT) will be used. The radiation dose that the participants will receive will be less than 0.0545, equivalent to 50 times less than an X-ray exam. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvements in quality of life To assess the perception of the quality of life, the 12-Item Health Survey (SF-12) will be used.;Improvements in mental health Mental health status will be assessed using the Depression, Anxiety, and Stress Scale (DASS - 21), and the calculation of the score will be based on a previous study. ;Improvements in anthropometric measurements The body mass index (BMI) will be used to measure nutritional status recommended by WHO and waist circumference (WC) will also be measured. ;Improvements in physical fitness Two motor tests will be performed to assess: (i) Strength resistance of lower limbs; (ii) Agility and Dynamic Balance. | — |
Countries
Brazil
Contacts
Public ContactAtila Trapé
Escola de Educação Física e Esporte de Ribeirão Preto
Outcome results
None listed