Effect of Aerobic Exercise on kidney in people with Chronic Kidney Disease

Effect of Aerobic Exercise on the progression of renal function in patients with advanced Chronic Kidney Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-5ctj37b

Enrollment

Registered

2026-06-30

Start date

2024-06-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease, stage 3

Interventions

This is a randomized, open-label, parallel-group clinical trial, with simple random allocation of participants to the intervention group and the control group. The randomization sequence was generated

due to the nature of the exercise intervention, blinding of participants and professionals responsible for the intervention was not possible. A total of 27 participants were randomized, with 46 alloca

Eligibility

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 years or older;residing in Botucatu or neighboring cities within a 50-km radius;with a maximum age of 80 years;with the physical capacity to perform exercise.

Exclusion criteria

Exclusion criteria: Physical incapacity evaluated by a nephrologist;pregnant women;individuals with neoplasms of any kind.

Design outcomes

Primary

Measure	Time frame
Expected Outcome 1:It was expected that the implementation of a supervised 12-week aerobic exercise program would maintain or improve renal function in patients with stages 3–4 Chronic Kidney Disease (CKD) compared with the control group. The primary outcome was to be assessed by the estimated glomerular filtration rate (eGFR), calculated using the CKD-EPI equation, with the expectation of reducing the progression of renal function decline. Additionally, improvements were expected in laboratory markers of kidney function, particularly serum creatinine and blood urea levels, as well as favorable effects on body composition and functional capacity.;Observed Outcome 1:Participants who underwent the supervised aerobic exercise protocol demonstrated a significant improvement in renal function compared with the control group after the 12-week intervention. Significant reductions were observed in serum creatinine levels (3.5 ± 1.3 vs. 5.2 ± 2.0 mg/dL; p = 0.022) and blood urea levels (104.6 ± 25.4 vs. 137.7 ± 33.3 mg/dL; p = 0.013), along with a significant increase in estimated glomerular filtration rate (eGFR) (20.4 ± 6.5 vs. 13.6 ± 7.2 mL/min/1.73 m²; p = 0.027). No statistically significant differences were observed between the groups in body composition or functional capacity, although favorable trends were identified. Overall, the findings demonstrated that the supervised aerobic exercise protocol was safe, feasible, and effective in attenuating the progression of renal dysfunction in patients with advanced Chronic Kidney Disease (CKD).	—

Measure

Time frame

Expected Outcome 1:It was expected that the implementation of a supervised 12-week aerobic exercise program would maintain or improve renal function in patients with stages 3–4 Chronic Kidney Disease (CKD) compared with the control group. The primary outcome was to be assessed by the estimated glomerular filtration rate (eGFR), calculated using the CKD-EPI equation, with the expectation of reducing the progression of renal function decline. Additionally, improvements were expected in laboratory markers of kidney function, particularly serum creatinine and blood urea levels, as well as favorable effects on body composition and functional capacity.;Observed Outcome 1:Participants who underwent the supervised aerobic exercise protocol demonstrated a significant improvement in renal function compared with the control group after the 12-week intervention. Significant reductions were observed in serum creatinine levels (3.5 ± 1.3 vs. 5.2 ± 2.0 mg/dL; p = 0.022) and blood urea levels (104.6 ± 25.4 vs. 137.7 ± 33.3 mg/dL; p = 0.013), along with a significant increase in estimated glomerular filtration rate (eGFR) (20.4 ± 6.5 vs. 13.6 ± 7.2 mL/min/1.73 m²; p = 0.027). No statistically significant differences were observed between the groups in body composition or functional capacity, although favorable trends were identified. Overall, the findings demonstrated that the supervised aerobic exercise protocol was safe, feasible, and effective in attenuating the progression of renal dysfunction in patients with advanced Chronic Kidney Disease (CKD).

—

Secondary

Measure	Time frame
No secondary outcomes are expected.	—

Countries

Contacts

Public ContactGabriel Rossi

Faculdade de medicina de botucatu - FMB/ Hospital das clinicas de Botucatu - HCFMB

Gabriel.rossi27@unesp.br+5514998610541

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026