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Analysis of dental biofilm's proteins and its relation with the effectiveness of the resin infiltration technique to prevent tooth breakdown in children who present molar-incisor hypomineralization (MIH)

Proteomal analysis of dental biofilm and its association with the effectiveness of the resin infiltration technique for the prevention of post-eruptive breakdown in children with molar-incisor hypomineralization (MIH)

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5bphrt
Enrollment
Unknown
Registered
2017-09-22
Start date
2016-10-03
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries

Interventions

The children will initially be examined for dental caries, MIH and dental biofilm. The exams will be carried out on portable stretcher, with the aid of a clinical mirror, OMS probe and compressed air
Group 2 - Occlusal sealing with high viscosity encapsulated glass ionomer. Those classified as low risk to dental caries will be randomized into: Group 3 - ICON® infiltrant in detected opacity and
Group 4 - No intervention. The procedures will follow the following protocols: - Application of the ICON® infiltrant in detected opacity: 1) Removal of the dental biofilm with the aid of a toothbrush
2) Topical anesthesia and intraseptal anesthesia, if necessary
3) Absolute insulation with rubber dam for moisture control
4) Application of ICON etch (hydrochloric acid 15%) for 2 minutes, followed by abundant washing
5) Application of ICON dry (alcohol 99%) for 30 seconds, followed by drying with air jets
6) Application of ICON infiltrant for 3 minutes, followed by removal of excess and photoactivation for 40 seconds
7) New application of ICON infiltrant for 1 minute followed by removal of overflows and new photoactivation for 40 seconds. - Occlusal sealing with high viscosity encapsulated glass ionomer: 1) Condi
2) Washing and drying the surface with cotton ball
3) Activat
Other
E06.323.428

Sponsors

Faculdade de Ciências da Saúde - Universidade de Brasília
Lead Sponsor
Secretaria de Educação do Distrito Federal
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Children with 8 years old; with good general health; with the first four permanent molars erupted, with at least one being affected by molar-incisive hypomineralization (MIH); who sign the terms of assent; whose parents have signed the TCLEs.

Exclusion criteria

Exclusion criteria: Children who have used any antifungal drug therapy or topical oropharyngeal antimicrobial medications for at least three months prior to collection; children outside the established age range; children with systemic, motor or psychological impairment.

Design outcomes

Primary

MeasureTime frame
Based on previous studies carried out in a population residing in the same region, it was estimated that the resin infiltration technique is able to reduce in half the loss of dental structure in MIH permanent molars that have white or yellowish-brown demarcated opacities, compared to the control group over a 24-month period

Secondary

MeasureTime frame
It is expected that there is correlation between the quality and amount of supragingival biofilm of the teeth evaluated with their protein profile and caries activity

Countries

Brazil

Contacts

Public ContactFernanda Raposo

Faculdade de Ciências da Saúde - Universidade de Brasília

fe.raposo6@gmail.com+55(61)981355697

Outcome results

None listed

Source: REBEC (via WHO ICTRP)