Knee osteoarthritis
Conditions
Interventions
This is a randomized, controlled clinical trial with three intervention arms, conducted with patients suffering from knee osteoarthritis. The study will be double-blind, with both patients and applica
Sponsors
Instituto Nacional de Traumatologia e Ortopedia
Instituto Nacional de Traumatologia e Ortopedia
Eligibility
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged between 40 and 75 years. Both sexes. Diagnosis of bilateral knee osteoarthritis according to the criteria of the American College of Rheumatology. Classified by radiographs using the Kellgren-Lawrence classification of grade III or less in both knees. Presenting with a full range of motion
Exclusion criteria
Exclusion criteria: Patients with a history of trauma, infection, or previous surgery in the affected joint. Patients with an alteration of the mechanical axis measurement of the lower limbs, varus or valgus greater than 5 degrees. Patients with inflammatory diseases. Corticosteroid infiltration in the last 6 weeks. Patients who underwent viscosupplementation in the past year. Patients who used NSAIDs in the two weeks prior. Patients with a body mass index greater than 40. Patients with a history of allergy to pollen or bird-derived products. Patients with active neoplasia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the clinical outcomes of hyaluronic acid injection and prolotherapy in the conservative treatment of mild to moderate knee osteoarthritis | — |
Secondary
| Measure | Time frame |
|---|---|
| To standardize the treatment protocol for mild to moderate knee osteoarthritis with prolotherapy | — |
Countries
Brazil
Contacts
Public ContactJosé Leonardo Rocha de Faria
Instituto Nacional de Traumatologia e Ortopedia
Outcome results
None listed