Heart Failure
Conditions
Interventions
Experimental group: 9 patients submitted to daily consumption of 50g of dark chocolate with 70% of cocoa (Theobroma cacao) offered by the researchers during the 4 week period. Chocolates were distri
Dietary supplement
B01.650.940.800.575.100.915.144
SP6.051.227
Sponsors
Programa de Pós Graduação em Ciências Cardiovasculares
Clínica de Insuficiência Cardíaca Coração Valente
Eligibility
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sedentary men or women between the ages of 40 and 80;Body mass index (BMI) above 18.5 kg / m 2 for both sexes;Stage 1, 2 and 3 ICC according to the NYHA classification criteria, (1994)
Exclusion criteria
Exclusion criteria: In use of any dietary supplement you have in your formulation Antioxidant nutrient and chocolate;Creatinine clearance less than 60 mL / min; Smokers or former smokers (less than two years of Smoking);Liver and / or pancreatic disease;Unstable angina pectoris; Allergy to chocolate or its derivatives;Patients with stage 4 heart failure according to the criterion of NYHA classification (1994); Physical examination with presence of edema;Presence of infectious, autoimmune or immunosuppressive disease; Presence of cardiac cachexia;Presence of hypoalbuminemia;Use of pacemaker;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effects of the ingestion of ChA with 70% cocoa on the inflammatory profile by measuring the lipid profile of the lipid profile by measuring the total cholesterol (mg / dL), HDL- (Mg / dL), LDL-cholesterol (mg / dL) and triglycerides (TG) (mg / dL), glycogen profile by measuring glycated hemoglobin (%), fasting glucose (mg / dL), anthropometric value BMI (kg / m2), abdominal circumference (cm), conicity index and waist / height ratio and body composition (WC) by fat mass (%) and lean mass (%) by bioimpedance and dual-emission x-ray absorptiometry (DEXA) of patients with heart failure . It was expected to find a reduction of 20 mg / dL of the CT value, an increase of 10 mg / dL of HDL-cholesterol, a reduction of 10 mg / dL of LDL-cholesterol and a reduction of 20 mg / dL of TG values. In the values of glycated hemoglobin it was expected to find a reduction of 2%, of fasting glucose 15 mg / dL, as for the value of the US-PCR was expected to find a reduction of 0.2 mg / dL. As for the values of anthropometry it was expected to find a reduction of the abdominal circumference of 2 cm, the waist / height ratio of 0.1 and the taper index of 0.5. In the CC evaluation it was expected to find a fat mass reduction of 2%. ;Improvement of the lipid profile after consumption of ChA with 70% cocoa, by a significant increase of HDL-cholesterol (mg / dL): 39 ± 9.3 vs 44 ± 11 and significant reduction of triglycerides (mg / dL): 138 ± 62.4 vs 114 ± 46 (p 0.05) was found in the percentage of fat mass (%) before and After consumption of dark chocolate 37.54 ± 6.87 vs. 37.73 ± 6.96, respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactGabrielle Rocha
Faculdade de Nutrição- UFF
Outcome results
None listed