Gingivitis
Conditions
Interventions
Test group: 30 patients with gingivitis will receive prophylaxis and/or supragingival scraping ("cleaning" on all teeth), biofilm collections (dental plaque) and gingival crevicular fluid (liquid betw
Dietary supplement
Other
G07.203.300.456.500
Sponsors
Universidade de São Paulo
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Systemically healthy individuals; presence of gingival inflammation in more than 30% of the sites; presence of 20 permanent teeth fully erupted, excluding third molars and teeth indicated for extraction; willingness to adhere to the study protocol.
Exclusion criteria
Exclusion criteria: Pregnant or lactating women; individuals with systemic involvement that may interfere with the study results; ingestion of antimicrobials and/or anti-inflammatories in the last 6 months and probiotics or oral antiseptics in the last month; use of medication with gingival implications; history or presence of periodontitis; presence of gingival disease not induced by plaque; known allergies to experimental materials; extensive prosthetic wraps; smoking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: Reduction in bleeding on probing; assessed dichotomously at 6 sites per tooth; considering a variation of at least 15% in the data collected at the beginning and at the end of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Reduction in the percentage of plaque; assessed by the Ainamo and Bay Visible Plaque Index at 4 sites per tooth; at the beginning and end of the study.;Expected outcome 2: Reduction in gingival inflammation; evaluated by the reduction in the levels of cytokines IL-1b, IL-1a, IL-8, RANTES, MCP-1 and MIP-1b present in the gingival crevicular fluid, through enzymatic immunoassays; at the beginning and end of the study.;Expected outcome 3: Reduction in the proportion of bacteria associated with periodontal disease and increase in the proportion of bacteria associated with periodontal health in dental biofilm; assessed by sequencing the 16S RNA gene; at the beginning and end of the study. | — |
Countries
Brazil
Contacts
Public ContactFlávia Furlaneto
Universidade de São Paulo
Outcome results
None listed