Hypertriglyceridemia and postprandial oxidative stress
Conditions
Interventions
This study will be divided into three stages. In the first step, the total antioxidant capacity will be assessed as well as the identification and quantification of phenolic compounds in beet leaves a
Dietary supplement
B01.650.940.800.575.100.200.399
Sponsors
Faculdade de Nutrição da Universidade Federal de Goiás
Faculdade de Nutrição da Universidade Federal de Goiás
Eligibility
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 15 Dyslipidemic volunteers; both genders; aged 20 to 60 years; non smokers.
Exclusion criteria
Exclusion criteria: Voluntiers in insulin use; diagnosis of diabetes mellitus; kidney disease; liver or thyroid disorders; Patients undergoing treatment for weight control; pregnant women; nursing mothers; menopausal women; women on hormone replacement; smoking; on medication for dyslipidemia control; history of a cardiovascular event in the last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in triglycerides, total cholesterol and fractions, determined by the enzymatic colorimetric method, with an automatic System Vitros Chemistry 950 XRL (Johnson & Johnson) and lowering blood pressure measured as recommended by the American Heart Association (AHA, 2005. For finding of the expected outcomes will be considered significance level for all 5 % of tests. ;It was observed attenuate the reduction of HDL-C, determined by the enzymatic colorimetric method, with an automatic System Vitros Chemistry 950 XRL (Johnson & Johnson) and decreased systolic blood pressure, measured with an Omron pressure monitor (HEM-7200 model Kyoto, Japan) with certificate of approval of Association for the Advancement of Medical Instrumentation and European Society of Hypertension, and measured as recommended by the American Heart Association (AHA, 2005). No changes were found in other outcomes. Deltas were obtained by the difference between each time and baseline. Data were presented as the mean ± standard error range and significance level for all tests was 5% | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in postprandial oxidative stress verified by analyzing the antioxidant capacity of plasma and activity of antioxidant enzymes and in inflammatory activity evaluated by the change in tumor necrosis factor levels, interleukin 6, interleukin 10, leptin, insulin and adiponectin levels being determined by means of a high sensitivity panel to humans (Milliplex, Millipore Corp., Missouri, USA) using Luminex xMAP technology (Multiple Analyte Profiling) which shall be considered an outcome occurred if there is any negative change.;Not analysed yet. | — |
Countries
Brazil
Contacts
Public ContactAnna Gomes
Faculdade de Nutrição da Universidade Federal de Goiás
Outcome results
None listed