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Effect of Different Toothpastes on Tooth Sensitivity During In-Office Whitening Treatment: A Clinical Study

Effect of Different Toothpastes on Dentin Sensitivity During In-Office Whitening Treatment: A Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-583pmfz
Enrollment
90
Registered
2026-06-29
Start date
2026-02-27
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity Esthetics, Dental

Interventions

This is a randomized controlled clinical trial. Randomization and allocation of selected individuals to their respective groups will be performed using the website www.random.org. All participants wil

Sponsors

Anhanguera - UNIDERP (Universidade para o Desenvolvimento do Estado e da Região do Pantanal)
Lead Sponsor
Anhanguera - UNIDERP (Universidade para o Desenvolvimento do Estado e da Região do Pantanal)
Collaborator

Eligibility

Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Individuals with good general health; aged between 18 and 40 years; with adequate oral hygiene, absence of caries and restorations in the anterior teeth; absence of periodontal diseases, and presence of upper canines with a shade of A2 or darker; as assessed by the Vita Classical scale under controlled light.

Exclusion criteria

Exclusion criteria: Participants with a history of whitening; restorations or endodontic treatment on anterior teeth; pregnant or breastfeeding women; severe internal discoloration; parafunctional habits; pathologies associated with sensitivity; use of fixed prostheses or orthodontic brackets; and those undergoing treatment with anti-inflammatory drugs; analgesics; antidepressants or for fibromyalgia.

Design outcomes

Primary

MeasureTime frame
It is expected that, should tooth sensitivity occur during whitening treatment, it will be controlled with the use of desensitizing toothpastes. The intensity of sensitivity will be measured using an electronic form Google Forms, with a scale of 0 to 10, where 0 represents the absence of dentin sensitivity and 10 the most intense painful sensation. The links will be sent individually to volunteers at three different times: 24 hours, 48 ??hours, and 7 days after each whitening session. From the responses, an average value will be calculated for each group, allowing for the evaluation of the effectiveness of sensitivity control. An improvement of approximately 30% is expected compared to the group receiving the placebo.

Secondary

MeasureTime frame
An improvement in tooth color is expected after the whitening treatment, and colorimetric evaluation will be performed before (T1) and after treatment (T2) using a spectrophotometer (Vitaeasyshade®). This will allow us to verify whether or not the use of the toothpastes interfered with the color result.

Countries

BR

Contacts

Public ContactSandrine Berger

Anhanguera - UNIDERP (Universidade para o Desenvolvimento do Estado e da Região do Pantanal)

berger.sandrineGgmail.com+55(43)991890454

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026