Cardiovascular disease, myocardial ischemia, heart failure.
Conditions
Interventions
Experimental group: 40 patients / volunteers of both genders, diagnosed with ischemic heart failure receive aqueous solution containing L-carnitine with 50 or 25 mg kg body weight. Control group: 20 p
Dietary supplement
Sponsors
Universidade Federal Fluminense
Instituto Nacional de Cardiologia/INC
Eligibility
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: Sixty adult patients; lucid; oriented; both genders; minimum age of 30 years and maximum age of 80 years; diagnostic systolic ischemic heart failure; requiring elective coronary artery bypass surgery; use of cardiopulmonary bypass (CPB); Ejection fraction of the left ventricle (LVEF) greater than or equal to 50% (Simpson method); left ventricular end-diastolic volume (LV Diastolic) greater than 150 mL / m²; end of the left ventricle systolic volume (LV Systolic) greater than 65 ml / m².
Exclusion criteria
Exclusion criteria: During treatment develop liver dysfunction; renal dysfunction; malabsorptive syndrome; stroke; sepsis; prolonged hemodynamic shock; Patients who discontinue supplementation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of at least 5% in the pre and post-intervention measurements by echocardiographic method remodeling and cardiac magnetic resonance imaging. To this volume are measured (mL) and weight (g), the wall thickness of the left ventricle (cm) and systolic and diastolic left ventricular (%). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are expected not. | — |
Countries
Brazil
Contacts
Public ContactSheila Guimarães
Universidade Federal Fluminense
Outcome results
None listed