Parkinson's Disease
Conditions
Interventions
Before applying the Transcranial Photobiomodulation protocol, participants will be randomly assigned to two groups of 20 participants each: (i) Intervention and (ii) Sham. Transcranial Photobiomodulat
100 mW
20 min) three times per week for six weeks, while Group (ii) Sham will also wear the equipment but will receive sham modulation under the same schedule (three times per week for six weeks)
E02.594.540
Sponsors
Pedro Paulo Gutierrez
Universidade Estadual Paulista (UNESP)
Eligibility
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants with Parkinson’s disease will be recruited from the Physical Activity Program for Patients with Parkinson’s Disease and the local community, based on the following inclusion criteria: (i) a diagnosis of idiopathic Parkinson’s disease made by a neurologist, according to the London Brain Bank criteria, and (ii) classification between stages 1 and 3 on the Hoehn and Yahr scale
Exclusion criteria
Exclusion criteria: Exclusion criteria include: (i) a history of orthopedic and/or visual impairments that prevent compliance with the experimental protocol; (ii) uncontrolled diseases that may affect peripheral sensory functions (e.g., diabetes); (iii) conditions that pose a risk for Transcranial Photobiomodulation, such as structural brain disease, epilepsy, or the use of potentially photosensitizing medications (e.g., imipramine, phenothiazines, lithium, chloroquine, hydrochlorothiazide, tetracycline); (iv) clinical signs of dementia, defined as a Mini-Mental State Examination score below 20; and (v) failure to complete the 18 required modulation/evaluation sessions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate quantitative gait parameters (velocity, step length and width, cadence, gait variability) under single-task and dual-task conditions, assessed before and after the intervention using a 5.74-meter-long pressure-sensor walkway (GAITRite®, CIR Systems Inc., Sparta, USA);To evaluate postural control parameters (sway area, mean amplitude, mean velocity, and mean frequency of center of pressure displacement) under single-task and dual-task conditions, assessed in a static position before and after the intervention using a force platform | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate cortical activity recorded before and after the intervention using functional near-infrared spectroscopy (fNIRS), through the analysis of cerebral oxygenation (oxy-Hb and deoxy-Hb) during walking and postural control tasks | — |
Countries
Brazil
Contacts
Public ContactPedro Gutierrez
Universidade Estadual Paulista "Julio de Mesquita Filho"
Outcome results
None listed