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Evaluation of endothelial function and cardiac autonomic and this relationship with clinical and functional aspects in patients with isolated chronic obstructive pulmonary disease and the coexistence of heart failure in exacerbation phase.

Exacerbation of COPD and COPD overlap heart failure and noninvasive ventilatory support: impact on endothelial function and cardiac autonomic modulation and relationship among cardiovascular outcomes and clinical and functional aspects

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-5778vq
Enrollment
Unknown
Registered
2020-03-24
Start date
2015-10-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstrutive Pulmonary Disease

Interventions

Implementation of noninvasive mechanical ventilation in both groups: 16 patients Isolated chronic obstructive pulmonary disease (COPD) and 16 COPD associated with heart failure (HF). Non-invasive vent
Device
E02.041.625.591

Sponsors

Universidade Federal de São Carlos
Lead Sponsor
Santa Casa da Misericórdia de São Carlos
Collaborator
Renata Gonçalves Mendes
Collaborator

Eligibility

Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: CCOPD patients; pulmonary function test values with forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) less than 0.7 and FEV1 less than 80% of predicted; associated with a history of drug treatment and signs and symptoms of COPD exacerbation; Typical HF signs and symptoms combined with a reduction in left ventricular (EF) fraction less than 50% by Doppler Echo, with forced expiratory volume in the first second (FEV1) / forced vital capacity (FVC) less than 0, 7 and lower FEV1 than 80% of the forecast).

Exclusion criteria

Exclusion criteria: Alcoholic patients and / or drug users who cause chemical dependency; patients using invasive mechanical ventilation; hemodynamic instability; presence of unstable angina; history of myocardial infarction in the last 6 months; patients who exacerbate again within the 30-day period.

Design outcomes

Primary

MeasureTime frame
Endothelial and cardiac autonomic function will be more committed at coexistence of the diseases (FMD and arterial stiffness and heart rate variability measures) than when compared to isolated COPD in exacerbation phase. And the application of noninvasive ventilatory support in this exacerbation phase results acutely in beneficial responses to the endothelial and cardiac autonomic function.—

Secondary

MeasureTime frame
The existence of an association between cardiovascular outcomes and clinical and functional aspects .—

Countries

Brazil

Contacts

Public ContactRenata Mendes

Universidade Federal de São Carlos

mendesrg@hotmail.com+55-16-33518448

Outcome results

None listed

Source: REBEC (via WHO ICTRP)