sepsis
Conditions
Interventions
This is a randomized, controlled, double-blind clinical study conducted in the Intensive Care Unit of Santa Casa da Misericórdia de Ouro Preto, in patients diagnosed with sepsis due to COVID-19 and ot
these are important allies in evaluating infectious parameters in critically ill patients. The secondary outcome will be the time to clinical improvement, defined as length of hospital stay or depende
Sponsors
Universidade Federal de Ouro Preto
Irmandade Santa Casa da Misericórdia de Ouro Preto
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 18 years or older; of both sexes; who were hospitalized in the intensive care unit (ICU) with a diagnosis of sepsis of any etiology according to the criteria defined by the fifth update of the Survivor Sepsis Campaign guidelines, published in 2021; who were hemodynamically compensated; who agreed to participate in the study through informed consent
Exclusion criteria
Exclusion criteria: Patients who present with hemodynamic instability during the study that makes enteral feeding unfeasible; pregnant or lactating women; allergy to propolis or bee products; occurrence of side effects due to the intervention; patients with severe renal or hepatic disorders; change in drug dosage; changes in diet or physical activity levels; consumption of other dietary supplements two months before the start of the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome:Supplementation with Brazilian green propolis, combined with standard sepsis treatment, is expected to reduce serum inflammatory markers in patients admitted to the intensive care unit, especially IL-8, IL-17A, IL-33, and CXCL-16, over a 10-day intervention period;Outcome found:No statistically significant differences were observed between the propolis and placebo groups in IL-8, IL-17A, and CXCL-16 levels at any of the time points analyzed; however, on the 10th day of treatment, a statistically significant increase in IL-33 was observed in the propolis group compared to the placebo group | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome: Supplementation with Brazilian green propolis is expected to be associated with a reduction in hospital mortality in patients with sepsis, compared to placebo;Outcome found: No significant difference was found in the reduction of in-hospital mortality in patients with sepsis compared to placebo | — |
Countries
BR
Contacts
Public ContactJacques Gabriel Horta
Universidade Federal de Ouro Preto
Outcome results
None listed