Metabolic Syndrome X, Potmenopause
Conditions
Interventions
In this prospective and open study, 87 women with age above 45 years and last menstruation at least 12 months prior to this study, who were randomly assigned to two study arms. One group (control) of
Dietary supplement
Sponsors
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista UNESP, Julio de Mesquita Filho
FAPESP - Fundação de Amparo a Pesquisa do Estado de São Paulo
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Women with: (1) date of last menstrual period for at least 12 months, (2) age between 45 and 65 years, (3) at least three criteria for the diagnosis of metabolic syndrome (waist circumference > 88 cm; triglycerides > 150 mg/dL; HDL cholesterol 130/85 mmHg or under therapy; fasting glucose > 100 mg/dL or under therapy).
Exclusion criteria
Exclusion criteria: The exclusion criteria were: (1) presence of cardiovascular disease manifests current or previous, (2) use drugs that affect lipoprotein metabolism (hormone therapy, statins), (3) alcoholic or drogaditas; (4) story autoimmune diseases, (5) history of malignancy; (6) intolerance or food allergy to fish; (7) insulin-dependent diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that supplementation with omega-3 900mg/dia occurs reducing of triglycerides between 7-25% in postmenopausal women with metabolic syndrome compared women undergoing diet alone.;It is expected that supplementation with omega-3 supplementation 900mg/dia improves the inflammatory status, by cytokines values, in postmenopausal women with metabolic syndrome compared women undergoing diet alone. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that supplementation with omega-3 900mg/dia improves parameters of metabolic syndrome, such as improvement of insulin resistance (IR), assessed by HOMA-IR (Homeostasis Model Assessment-Insulin Resistant) calculated by the formula: Insulin (mU / mL) x fasting plasma glucose (mg / dl) / 405, with values?? > 3.6 indicate IR. Thus, the effect on blood pressure, reducing the values ??of systolic and diastolic blood pressure assessed by direct measurement of pressure. | — |
Countries
Brazil
Contacts
Public ContactAna Paula Tardivo
Faculdade de Medicina de Botucatu da Universidade Estadual Paulista UNESP, Julio de Mesquita Filho
Outcome results
None listed