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Cell count with changes in the nucleus in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobiana Photodynamic Therapy (Laser Light)

Quantification of micronuclei in individuals with Periodontitis undergoing Non-Surgical Periodontal Treatment associated or not with Antimicrobial Photodynamic Therapy: randomized clinical trial - aPDT antimicrobial photodynamic therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-55s62wd
Enrollment
Unknown
Registered
2024-10-31
Start date
2024-05-09
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

This is a randomized clinical trial with a total of 40 participants with periodontitis, who meet the eligibility criteria. They will be randomly allocated into 2 intervention groups, through a draw in
E02.186.500
E06.721.189.350
E05.393.560.598

Sponsors

Universidade Federal do Rio de Janeiro
Lead Sponsor
Universidade Federal do Rio de Janeiro
Collaborator
Faculdade de Odontologia da Universidade Federal do Rio de Janeiro
Collaborator

Eligibility

Age
35 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient with periodontitis; over 35 years old; both genders; with 10 teeth or more in the mouth

Exclusion criteria

Exclusion criteria: Patients with severe motor difficulties; people with type 1 and type 2 diabetes; of chronic kidney disease; from malignant neoplasms; Acquired Immunodeficiency Syndrome; of autoimmune diseases; pregnant or breastfeeding women; immunosuppressed by medication; have evidence of other ASA III and IV systemic diseases; smokers or ex-smokers for less than ten years; users of orthodontic appliances; have a history of using steroidal or non-steroidal anti-inflammatory drugs in the previous three months and during the study; use of antibiotics in the last 4 months or any dietary supplements, including antioxidant supplements, in the last six months before the study; followed any specific diet in addition to their usual diet during the last six months and had received supra- and subgingival scaling and/or periodontal surgery in the six months prior to the study

Design outcomes

Primary

MeasureTime frame
Measurement of the frequency of micronuclei (MNs) after non-surgical periodontal treatment associated or not with antimicrobial photodynamic therapy (aPDT) with the validation of a possible strategy and improvement of already consolidated periodontal health care protocols—

Secondary

MeasureTime frame
No secondary outcomes are expected.—

Countries

Brazil

Contacts

Public ContactMaria Cynésia de Barros

Universidade Federal do Rio de Janeiro

cynesiaster@gmail.com+55-21-39382103

Outcome results

None listed

Source: REBEC (via WHO ICTRP)