Essential hypertension (primary)
Conditions
Interventions
This is a single-center, blinded, parallel-group-based, prospective, randomized, controlled, blinded-allocation clinical trial with an 8-week follow-up, analyzed with an intention-to-treat approach. R
E02.190.525.374
Sponsors
Universidade Federal de Mato Grosso do Sul
Hospital Universitário Maria Aparecida Pedrossian
Eligibility
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Subjects of both sexes; aged between 30 and 70 years; patients with arterial hypertension or using at least one antihypertensive medication; stage I systemic arterial hypertension with a minimum diagnosis of 1 year; use of unchanged antihypertensive medication for at least 2 months; did not participate in regular exercise programs 3 or more times a week in the last 3 months prior to the study; are able to read; speak and understand Portuguese
Exclusion criteria
Exclusion criteria: Subjects who do not adhere to the experimental protocol; who have a diagnosis of heart failure greater than or equal to New York Heart Association I; chronic obstructive pulmonary disease; cognitive impairment that makes it impossible to understand the protocols; or psychiatric disease; previous stroke; neuromuscular disease; asthma; uncontrolled diabetes; vascular disease peripheral; obesity grade III; renal failure of stage greater than 2; sleep apnea; malnutrition; or other diseases that interfere with the performance of the protocol; and lack of more than two sessions of supervised meditation; secondary hypertension; individuals with contraindications to performing a symptom-limited maximal exercise test; and individuals who regularly practice meditation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate changes in blood pressure under normoxia and under hyperoxia, analyze changes in carotid body activity at rest; all after 8 weeks of meditation, compared to the control group. Any blood pressure difference for normoxic or hyperoxic test greater than 5.9 mmHg, as determined by our reliability study, after 8 weeks will be considered a clinically significant result. To the best of our knowledge, there is no reproducibility study in hypertensive adults for resting carotid body activity | — |
Secondary
| Measure | Time frame |
|---|---|
| To analyze changes in resting ventilatory variability and resting ventilatory variability, both after 8 weeks of meditation, compared with the control group. Any difference in standard deviation 1 greater than 1.2 liters after 8 weeks of meditation will be considered a clinically significant result | — |
Countries
Brazil
Contacts
Public ContactTiago;Paulo Augusto;Muller
Universidade Federal de Mato Grosso do Sul;Universidade Federal de Mato Grosso do Sul
Outcome results
None listed