Chagas' Cardiomyopathy
Conditions
Interventions
Ganglionic or placebo electrical stimulation will be applied randomly and acutely for 30 minutes in the experimental and control groups. The experimental group will be composed of 10 male volunteers w
Device
E02.331.800
Sponsors
Faculdade de Ceilândia da Universidade de Brasília
Faculdade de Ceilândia da Universidade de Brasília
Eligibility
Sex/Gender
Male
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criterias for healthy subjects were aged > 45 years; absence of previous history of disease or surgical procedure and functional alterations during initial assessment or found in anaminesis that may interfere with the assessment of FMD. The criterias for chagasic subjects were aged > 45 years; consistent symptoms with chagasic heart failure III-IV classes of New York Heart Association (NYHA); stable heart failure drug therapy; left ventricular ejection fraction < 45%.
Exclusion criteria
Exclusion criteria: Exclusion criterias for healthy subjects were complications or cognitive/psychiatric disorders that hinder the realization of the protocol; electrical stimulation intolerance. The exclusion criterias for chagasic subjects were decompensated heart failure; uncontrolled diabetes; history of recent infection (last 03 months); corticosteroid use (last 03 months); valvular heart disease; unstable angina; acute myocardial infarction (last 03 months); obstructive hypertrophic cardiomyopathy; heart failure due to pericardial disease or corrected valvular disease; history of pulmonary / smoking disease (last 12 months); peripheral vascular disease; chronic use of oxygen therapy; previous implantation of a pacemaker or cardiac defibrillator; and systolic blood pressure at rest > 200 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increase of the brachial artery dilation by at least 3% as measured by the flow-mediated dilation (FMD) technique obtained by ultrasound imaging. The analysis of the FMD should have been carried out until 04/30/2018. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected. | — |
Countries
Brazil
Contacts
Public ContactGerson Cipriano Junior
Faculdade de Ceilândia da Universidade de Brasília
Outcome results
None listed