osteoarthritis, knee
Conditions
Interventions
This is a single-blind randomized controlled clinical study, blinded by the evaluator and not blinded by the participants and the physiotherapist who conduct the intervention. Randomization carried ou
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Sponsors
Programa de Pós-Graduação em Fisioterapia, Departamento de Fisioterapia, Universidade Federal de São Carlos
Hospital Universitário da Universidade Federal de São Carlos
Eligibility
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 40 years or older,both sexes, clinical (American College of Rheumatology) and/or radiological (K/L II, III or IV) diagnosis of knee osteoartritis, pain as a primary symptom, mean pain intensity = 4 on numerical pain scale (NPS) in the 7 days before the evaluation
Exclusion criteria
Exclusion criteria: Trauma or muscle damage, physiotherapy (more than once a week), regular physical activity (= 150 minutes per week), corticosteroid infiltration in last 30 days, history of knee surgery(s), rheumatic diseases, chronic painful syndromes, peripheral neuropathy, motor deficit, neuromuscular diseases, severe or uncontrolled cardiovascular diseases, health conditions that risk the safety of participants, pregnancy, recent history of substance dependence, inability to understand and follow instructions, inability to move without outside assistance, and initiation of treatment programs during
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pressure pain thresholds (main outcome): it is expected to find, in group exercise, an increase in pressure pain thresholds (points: knee medial joint line, anterior tibial muscle, center of the patella, quadriceps muscle, contralateral tibial anterior, contralateral center of patella, contralateral forearm) after the intervention (14 weeks), verified with algometry (3 measurements per point, speed of increase in pressure 0.33 kg/s, with pressure algometer ITO OE220), from a variation of 0.57 kg to the over time and/or significant differences in time group interaction (p<0.05), compared to the education group.;Conditioned pain modulation: it is expected to find, in group exercise, a reduction in the values ??of conditioned pain modulation after the intervention (14 weeks), verified by the method differences in the intensity of pain provoked by a fixed pressure stimulus before and after immersion of the hand in ice water (4°C) in the joint line medial knee and forearm, from variation of more than 10.6% over time and/or significant differences in time group interaction (p<0.05),compared to the education group.;Temporal summation: It is expected to find, in group exercise, a reduction in temporal summation after the intervention (14 weeks), verified by the method differences in pain intensity in the first and tenth stimuli of a sequence of 10 pressure stimuli with an algometer in the quadriceps muscle, based on significant differences over time and/or in group interaction time (p<0.05), compared to the education group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life: it is expected to find, in the exercise group, an increase in quality of life (increase in the score) after the intervention (14 weeks), verified by the application of the 12-item Health Survey (SF-12), based on differences over time greater than 2.7 and 1.4 points on the physical and mental subscales, respectively, and/or differences between post-intervention groups of 1.8 and 1.5 points on the physical and mental subscales, respectively, and/ or significant differences in the time group interaction (p<0.05) compared to the education group.;Sleep quality: it is expected to find, in the exercise group, an increase in sleep quality (score reduction) after the intervention (14 weeks), verified by applying the Pittsburgh Sleep Quality Index questionnaire, based on differences over time greater than 4.4 points and/or significant differences in the time group interaction (p<0.05) compared to the education group.;Pain and physical function: it is expected to find, in the exercise group, a reduction in pain and physical disability (reduction of final score), verified by the application of the Western Ontario and McMaster Universities (WOMAC) questionnaire, based on differences over time of 5.3, 11.8 and 20.1 points for people with mild, moderate or severe symptoms respectively, and/or significant differences in the time group interaction (p<0.05) compared to the education group.;Punctate pain intensity: it is expected to find , in group exercise, a reduction in the pain intensity values ??is expected, verified by the 2s stimulus method with standard 300g von Frey monofilament on the ventral surface of the forearm, based on differences from a 15% variation over time and /or significant differences in time group interaction (p<0.05), compared to the education group.;Knee extensor muscle strength: It is expected to find, in the exercise group, an increase in the strength of the knee extensor muscles, verified by the maximum voluntary isometric contraction met | — |
Countries
Brazil
Contacts
Public ContactPaula Venturini
Programa de Pós-Graduação em Fisioterapia, Departamento de Fisioterapia, Universidade Federal de São Carlos
Outcome results
None listed