Parkinson's disease
Conditions
Interventions
The strength and functional training protocol will have an intervening period of 12 weeks, 3 months, and drills will be performed twice a week. Every four weeks training loads will be adjusted progres
Other
I02.233.543
Sponsors
Fundação de Amparo a Pesquisa do Estado de São Paulo - FAPESP
Escola de Educação Física e Esporte da Universidade de São Paulo
Eligibility
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional. All patients must present the clinical diagnosis of Parkinson's disease obtained by a neurologist, to present between 50 and 80 years of age, to present Parkinson's disease between stages 2 and 3, do not perform regular exercise weights six months before starting the training intervention.
Exclusion criteria
Exclusion criteria: Patients who present symptoms of dementia, depression, joint problems, hypertension and stroke will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Timed up and go ;The primary endpoint of this study is to raise the test, go back and commonly known as timed up and go. In this test the patient has to get up from a chair, walk three meters around an obstacle, and sit back in the chair again. In this test the time is measured which it takes the patient to the route previously described. The analysis of the primary endpoint will be a comparison of the test stand, go back and forth on all patients randomized into three treatment arms: group strength training, functional training group and control group. This will be used for an analysis of mixed models, taking the three treatment arms and the time before and after training as fixed factors and patient as random factor, the level of significance is p <0.05. If the analysis of mixed models for the primary outcome reveal a statistically significant difference between the groups that receive different interventions and the control group demonstrate that both trainings are effective in improving time to get up, walk back and forth in patients with Parkinson's disease. On the other hand, if the analysis of mixed models provide a statistically significant difference between the group and the group strength training functional training demonstrate that an intervention is more effective than another in improving time to get up, walk back and in patients with disease Parkinson's. It is expected that patients in group functional training after three months of training to obtain a better performance on the test stand, go back and compared with patients in group strength training, since this type of training works motor control, proprioception neuromuscular and aspects that are vital for patients with Parkinson's disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength of the lower limb, lower limb muscle mass, severity of motor symptoms, activities of daily living, quality of life, balance, cognition, anxiety, sleep quality, fear of falling, presynaptic inhibition of the lower limb, lower limb reciprocal inhibition, and ACTN3 gene.;Muscle strength of the lower limb is defined as the maximum load that the patient can lift once. This will be measured by the test in one repetition maximum leg press exercise, which indicates the maximum strength of the patient. The muscle mass of the lower limb is measured using magnetic resonance imaging, which indicate the cross-sectional area of the quadriceps femoris muscle of the patient. The severity of motor symptoms will be measured by the Unified Parkinson's Disease Rating Scale part III. There are 14 items and the score on each item ranges from 0 to 4, and the maximum value indicates greater disease involvement and minimum normal. The daily activities will be measured by the Unified Parkinson's Disease Rating Scale part II. There are 13 items and the score on each item ranges from 0 to 4, and the maximum value indicates lower performance in the execution of daily life and the minimum optimum performance. The quality of life will be measured by the Quality of Life Questionnaire Parkinson's Disease PDQ-39. There are 39 questions each question ranges from 0 to 4. The issues are referred to how often the individual has passed difficulties arising from Parkinson's disease for the last month and assesses mobility, activities of daily living, emotional state, social stigma, social support, cognition, communication and discomfort physical. Lower scores indicate better quality of life while higher scores indicate poorer quality of life. The balance will be assessed by 3 instruments. The first is the Berg Balance Scale to evaluate the static and dynamic balance. This scale consists of 14 tests that assess the ability of the individual to sit, stand, reach, turn around yourself | — |
Countries
Brazil
Contacts
Public ContactCarlos Ugrinowitsch
Escola de Educação Física e Esporte da Universidade de São Paulo
Outcome results
None listed