Alzheimer Disease
Conditions
Interventions
Participants were evaluated at baseline and after 12 weeks. The intervention group participated in a multimodal exercise class lasting 60 minutes, three times a week on non-consecutive days, including
Behavioural
E02.760.169.063.500.387
Sponsors
Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM
Programa de Pós-Graduação em Atenção à Saúde, Universidade Federal do Triângulo Mineiro - UFTM
Eligibility
Inclusion criteria
Inclusion criteria: Elderly with clinical diagnosis of Alzheimer's disease, according to the Diagnostic and Statistical Manual of Mental Disorders; Severity of mild and moderate dementia according to the Dementia Clinical Assessment Score; Availability for participation of the evaluations proposed by the researcher; Elderly persons and their respective caregivers who agree to the study procedures and who agree to sign the Informed Consent Form.
Exclusion criteria
Exclusion criteria: Elderly patients with coronary heart disease, cardiac arrhythmias, uncontrolled hypertension and angina symptoms, or who have any absolute restriction on physical exercise; Elderly people with visual, auditory, dizzying or other impairments that impair locomotion and balance; Elderly with other neuropsychiatric conditions; Frequency less than 70% in the program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: Modifications in the executive and attention functions through the Frontal Assessment battery in the elderly with Alzheimer's disease in training of 12 weeks when compared to the controls;Outcome found 1: Improvements in cognitive and attention functions by means of the Frontal Assessment battery in the elderly with Alzheimer's disease in training of 12 weeks when compared to the controls, from the observation of a variation of 6.94% in the pre and post intervention measurements | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome found 1: Modifications in plasma levels of BDNF by Enzyme Linked Immunosorbent Assay using the BDNF Emax in elderly with Alzheimer's Disease participating in a exercise training of 12 weeks in relation to the controls;Outcome found 2: Increased plasma BDNF level of at least 200% from Enzyme-Linked Immunosorbent Assay using BDNF Emax in Alzheimer's Disease Elderly subjects in training of 12 weeks when compared to controls.;Outcome found 3: Modifications in plasma levels of inflammatory cytokines by means of the matrix of cytometric accounts in elderly patients with Alzheimer's disease participating in a 12-week exercise training in relation to controls;Outcome found 4: Decreased levels of plasma Interleukin 2 in the elderly group with Alzheimer's disease in 12-week exercise training compared to controls of at least 5%, through the matrix of cytometry accounts | — |
Countries
Brazil
Contacts
Public ContactJair Virtuoso Junior
Federal University of Triângulo Mineiro - UFTM
Outcome results
None listed