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Comparative study of donated corneas with and without Descemet's membrane in corneal transplants with perforation during surgery

Comparison of donated corneas with and without Descemet's membrane in deep anterior lamellar corneal transplantation with intraoperative perforation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-52r82gy
Enrollment
Unknown
Registered
2024-07-23
Start date
2024-08-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cornea transplant status, Keratoconus, Corneal opacity, Cornea injuries

Interventions

This is a prospective randomized comparative study that will be carried out at the Hospital Oftalmológico de Sorocaba (HOS) in patients undergoing deep anterior keratoplasty (DALK) who present intraop
E02.095.147.725.225

Sponsors

Hospital Oftalmológico de Sorocaba
Lead Sponsor
Hospital Oftalmológico de Sorocaba
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients 18 years of age or older; patients indicated for deep anterior lamellar keratoplasty (DALK) by the Hospital Oftalmológico de Sorocaba (HOS); patients who agree to participate in the study

Exclusion criteria

Exclusion criteria: Patients who do not present intraoperative perforation of the Descemet's membrane; patients requiring conversion to penetrating keratoplasty (PK); pregnant or breastfeeding woman; patients who at some point give up participating

Design outcomes

Primary

MeasureTime frame
It is expected to find a double anterior chamber increase in patients undergoing deep anterior lamellar transplantation (DALK) who had intraoperative perforation and received donor corneas with Descemet's Membrane (MD), proven by biomicroscopy and/or optical computed tomography (OCT) of anterior segment.—

Secondary

MeasureTime frame
To compare the visual and topographic results and the complication rate of patients undergoing deep anterior lamellar transplantation (DALK) who had intraoperative perforation of the recipient's Descemet's Membrane (MD) and received donor corneas with or without Descemet's Membrane (MD), through visual acuity examination, biomicroscopy, corneal tomography, specular microscopy and contact lens testing.—

Countries

Brazil

Contacts

Public ContactJosé Alvaro;Constantin Philippe Gomes;Salha

Universidade Federal de São Paulo ;Hospital Oftalmológico de Sorocaba

japgomes13@gmail.com.br;constantinsalha@gmail.com+55(11) 5085-2082;+55(086)994908329

Outcome results

None listed

Source: REBEC (via WHO ICTRP)