Periodontal Pocket
Conditions
Interventions
First Objective: To evaluate the effect of i-PRF as an adjuvant therapy to Scaling and Root Planing (SRP) in Non-Surgical Periodontal Therapy (NCPT) of patients diagnosed with periodontitis.
Second Ob
Clinical analysis time (repeated measure) at three levels (Baseline - before periodontal therapy, forty-five days after periodontal therapy and ninety days after periodontal therapy)
Two-level radiographic analysis time (Baseline - before periodontal treatment and ninety days after periodontal therapy)
Response variables: Plaque index (PI), probing pocket depth (PS), gingival rece
levels of cytokines IL-1ß, TNF-a and IL-10
Methods of analysis: Clinical periodontal examination, radiographic and collection of crevicular gingival fluid
Sample Size: Thirty patients
The randomizatio
Clinical analysis time (repeated measure) at three levels (Baseline - before periodontal treatment, forty-five
Sponsors
Faculdade de Odontologia da Universidade Federal de Uberlândia
Faculdade de Odontologia - Universidade Federal de Uberlândia
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with Stage III Periodontitis, with 5 mm or more of interproximal attachment loss or radiographic bone loss extending to the apical half or third of the root; may have vertical bone loss of up to 3 mm; grade II or III furcation lesions and moderate ridge defect; direct evidence of non-progression of attachment loss for 5 years or indirect evidence of bone loss/year up to 0.25 mm; patients with large accumulation of biofilm but little periodontal destruction; minimum of 20 teeth present and presence of two pairs of contralateral teeth with proximal periodontal sites presenting probing depth and clinical attachment level = 5 mm
Exclusion criteria
Exclusion criteria: Underage patients; patients who do not agree with the informed consent and do not sign it; tooth loss of 5 or more teeth due to periodontitis; positive history of antibiotic therapy in the last six months; positive history of nonsurgical periodontal therapy in the last six months; systemic involvement that may interfere with disease progression or response to treatment; need for antibiotic prophylaxis for routine dental procedures; use of anti-inflammatory drugs for a long period of time; smoking; pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the plaque index on dental surfaces, which will be verified by the percentage of tooth surfaces with plaque deposits stained with evidencing solution and it is expected to find a reduction in this plaque index;To evaluate the pocket depth on probing, which will be verified using a periodontal probe, after 90 days of non-surgical periodontal therapy, it is expected to find a reduction in this probing, with an expected depth equal to or less than 3 mm | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the presence of bleeding on probing, which will be verified at the time of probing with the use of the periodontal probe, it is expected that, after 90 days of non-surgical periodontal therapy, there will be no bleeding on probing | — |
Countries
Brazil
Contacts
Public ContactPriscilla Soares
Faculdade de Odontologia - Universidade Federal de Uberlândia
Outcome results
None listed