Hydroxymethylglutaryl-CoA Reductase Inhibitors
Conditions
Interventions
D02.455.426.559.847.638.400.900
This is a randomized, double-blind, split-mouth clinical trial to assess the osteoinductive action of 20mg simvastatin, using the post-extraction socket of the lower third molars as a study model. On
on the control side (group B) only the clot remained. A total of 22 patients underwent two extractions of third molars at the same surgical time, each performed in different sides of the mandible. All
Drug
Procedure/surgery
Sponsors
Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE
Universidade Federal de Pernambuco
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: adult patients aged between 18-40 years old, of both genres, of any ethnicity, healthy, without allergy to the drugs used in the research or its components and who are not using any other medication. All patients must have both lower third molars, included, with the same inclusion pattern according to the Pell & Gregory classification, healthy, with indication of extraction and without signs of pericoronitis or inflammation.
Exclusion criteria
Exclusion criteria: The exclusion criteria were: patients with an inability to open their mouth for surgery; exceed 40 minutes in any surgery; fracture or postoperative infection; recent history of chemotherapy and / or radiation to the head and neck; giving up participating in the research at some point; make use of medications that have a known interaction with any drugs used in the study; smokers, pregnant or lactating women; did not perform the tests requested in the postoperative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The bone volume, verified by the analysis of 2 cone-beam scans for each patient, based on the observation of a variation of at least 4.23 mm³ in favor of the intervention group.;The Percentage of bone volume (BV / TV), verified by analysis of 2 cone-beam tomographies for each patient, based on the observation of a variation of at least 0.07 mm³ in favor of the intervention group. | — |
Secondary
| Measure | Time frame |
|---|---|
| The pain was verified using the visual analog scale (VAS), based on the observation of a significant difference between the groups at the following times: 2, 4, 6, 8, 24, 48 and 72h (p <0.05).;The swelling, verified through the evaluation through the measurement of three facial measures, from the verification of a variation of at least 2.23mm in favor of the test group after 72h.;Alveolar healing, verified through the Landry index, based on the finding of a worse local tissue repair profile in the test group (p <0.01) compared to the control group. | — |
Countries
Brazil
Contacts
Public ContactJiordanne Diniz
Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE
Outcome results
None listed