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Prevention of drug-induced Bone Necrosis in the oral cavity in Cancer patients undergoing Tooth Removal – randomized clinical trial

Prevention of drug-induced jaw Osteonecrosis in oncological patients undergoing Exdontics – randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-4zsh6g8
Enrollment
Unknown
Registered
2024-04-03
Start date
2024-03-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bisphosphonate-Associated Osteonecrosis of the Jaw

Interventions

A randomized clinical trial will be carried out through a draw using brown, sealed and numbered envelopes, which will indicate the treatment protocol to be instituted, with the purpose of comparing th
E02.594.540
E06.892

Sponsors

Sociedade Pernambucana de Combate ao Câncer
Lead Sponsor
Universidade de Pernambcuo
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age; both genders; presence of teeth requiring simple extraction; patient submitted to medications that induce osteonecrosis of the jaw for antineoplastic treatment

Exclusion criteria

Exclusion criteria: Patients who underwent radiotherapy treatment in the head and neck region; patient diagnosed with metastasis in gnathic bones; patients with any known contraindications or allergies to methylene blue or some of the prescribed medications; patients with any clinical impediment to performing photobiomodulation

Design outcomes

Primary

MeasureTime frame
It is expected that photodynamic therapy will have a prophylactic effect on the development of drug-induced osteonecrosis of the jaw in cancer patients undergoing tooth extraction.—

Secondary

MeasureTime frame
No secondary outcomes are expected.—

Countries

Brazil

Contacts

Public ContactLucas Ribeiro

Universidade de Pernambcuo

fop.posgraduacao@upe.br+55(81)31833674

Outcome results

None listed

Source: REBEC (via WHO ICTRP)