Critical patients, sepsis, acute kidney injury, dialysis, vancomycin
Conditions
Interventions
One group of 219 patients will be submitted a clinical evaluation of data collected obtained through patient consultation and medical records, from the initial prescription of vancomycin to the end of
Other
Sponsors
Departamento de Clínica Médica da Faculdade de Medicina de Botucatu
Departamento de Clínica Médica da Faculdade de Medicina de Botucatu
Faculdade de Medicina de Botucatu
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Septic patients older than 18 years using vancomycin for at least 48 hours admitted to 2 intensive care units and 4 wards (clinical and surgical). Patients using vancomycin and requiring acute renal support will be included in an additional vancomycin pharmacokinetic / pharmacodynamic research protocol
Exclusion criteria
Exclusion criteria: Patients under 18 years old; Pregnant women; stage 5 CKD (creatinine clearance less than 15 mL / min, according to the MDRD formula); Kidney transplant recipients; Patients taking vancomycin for less than 48 hours and those admitted or who progressed with acute kidney injury prior to the start of their use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Higher incidence of acute kidney injury and higher mortality in the group with toxic levels of vancocinemia evaluated in the period of 1 year. The sample size was calculated considering that unfavorable clinical outcomes (AKI or mortality) will be 20% more prevalent in patients with vancomycin subtherapeutic or toxic levels, alpha error of 0.05 and study power of 80%, being necessary 73 patients in each group, that is, 219 patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of removal of vancomycin during dialysis therapy. Quantification of antimicrobials in the biological matrix (plasma) will be performed through high performance liquid chromatography (HPLC) using validated and developed bioanalytical methods. The analytical stage will be carried out from February 2018 until June 2018. | — |
Countries
Brazil
Contacts
Public ContactWelder Zamoner
Departamento de Clínica Médica da Faculdade de Medicina de Botucatu
Outcome results
None listed