FindTrial
Sign In

Influence of body fat in energy expenditure of People living with HIV and Aids

Influence of Brown Adipose Tissue in energetic metabolism of People living with HIV and Aids

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-4zrmm4
Enrollment
Unknown
Registered
2017-10-31
Start date
2017-01-02
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Men, HIV-associated lipodystrophy syndrome

Interventions

The aim of this study is to evaluate the influence of brown adipose tissue on energy expenditure of people living with HIV/aids. This study will be a cross-sectional study and will be composed of 33 a
Other
E01.370.350.825
E05.196.131.655
E05.196.712.224
E01.370.225.500.384.100.119
D06.472.699.042

Sponsors

Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Lead Sponsor
Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Adult subjects; male; stable weight for 3 months; body mass index between 18.5 and 29.9 kg / m2; in the case of HIV seropositive patients group using antiretroviral therapy for at least 6 months; T-CD4 cell count greater than 200 cells / mm3; undetectable viral load

Exclusion criteria

Exclusion criteria: Changes of thyroid function; use of glucocorticoids in the last 6 months; use of lipid-lowering drugs; use of oral anti-diabetics; use of beta-blockers; use of benzodiazepines; signs and symptoms of opportunistic diseases in the case of HIV seropositive patients

Design outcomes

Secondary

MeasureTime frame
Secondary outcomes are not expected—

Primary

MeasureTime frame
Expected Outcome 1: increase in UCP1 gene expression assessed by the real-time polymerase chain reaction method based on the finding by previously published studies of a variation of at least 10% in measurements between groups with HIV with lipodystrophy and the control group (healthy). Measurements will be taken after the end of the study.;Expected Outcome 2: increased resting energy expenditure assessed by indirect calorimetry based on the finding by previously published studies of a variation of at least 8% in measurements between HIV-positive and lipodystrophy groups. Measurements will be taken after the end of the study.—

Countries

Brazil

Contacts

Public ContactAnderson Navarro

Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

navarro@fmrp.usp.br+55(16)33150745

Outcome results

None listed

Source: REBEC (via WHO ICTRP)