Healthy volunteer. Endothelium Vascular
Conditions
Interventions
Therapeutic ultrasound will be applied at an intensity of 0.4 W/cm2, for five minutes. The continuous, pulsed and control (equipment off) waveforms will be randomized by a volunteer researcher whereas
Group 2 = pulsed ultrasound, n=30
Group 3 = continuous ultrasound, n=30). All volunteers (thirty) will undergo the three interventions and evaluated on three consecutive days.
Other
Sponsors
Universidade Federal do Rio Grande
Universidade Federal do Rio Grande
Eligibility
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Literate volunteers. Aged between 18 and 40 years old. Body mass index (BMI: kg/m2) less than 30. Have no symptoms of musculoskeletal disorders. Not making use of medication (except contraceptives), smoking and alcohol. Have no previous diagnosis of rheumatic diseases, cardiovascular, metabolic, neurological, oncological, haematological and immunological. Absence of psychiatric or cognitive problems.
Exclusion criteria
Exclusion criteria: Volunteers who performed high-intensity physical activity 72 hours before evaluations; presence of inflammatory response measured by the ultrasensitive PCR >3mg/dL, fibrinogen 400mg/dL, leukocytosis >11,000 x103/mm3, body temperature less than 38ºC, consumer beverages containing caffeine or alcohol, arterial diameter between 5mm and endothelial dysfunction assessed by FMD (<8%).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endothelium-dependent vasodilation. Arterial endothelial function will be evaluated by Flow-Mediated Vasodilation (FMD) technique, according to Guidelines of the American Heart Association (Correti et al., 2002), by brachial artery ultrasonography (Logiq P6, GE Healtcare, GE Ultrasound Korea Ltda., South Korea) using 5-12 MHz linear transducer. The endothelium-dependent vasodilation is measured after reactive hyperemia of 5 minutes of occlusion of brachial artery (50mmHg above systolic pressure). Responses of the vessel diameter to reactive hyperemia will be measured respectively before and after insufflation of cuff. The results will be expressed by relative percentage changes of brachial artery diameter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endothelium-independent vasodilation. The endothelium-independent vasodilation will be evaluated using sublingual nitroglycerin spray (0.4mg). The results will be expressed by the relative percentage changes of brachial artery diameter. | — |
Countries
Brazil
Contacts
Public ContactLuis Signori
Universidade Federal do Rio Grande
Outcome results
None listed