Hypoxemic Acute Respiratory Insufficiency
Conditions
Interventions
This is a non-blind randomized controlled trial. Patients from 1 month to 18 years of age admitted to the Pediatric Intensive Care Center (CTIP) of the Hospital das Clínicas da Faculdade de Medicina d
C08.618.846.688
Sponsors
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Eligibility
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: Patients 1 month to 18 years old; both genders; admitted to the Pediatric Intensive Care Center -CTIP - of the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto, University of São Paulo -HCFMRP USP - with hypoxemic acute respiratory failure (PaO2/FiO2 less than or equal to 300 mmHg) and/or P -ARDS undergoing invasive mechanical ventilation for less than 24 hours
Exclusion criteria
Exclusion criteria: Chest circumference below 38 cm; tracheal tube without cuff; hemodynamic instability; chest imaging showing pneumomediastinal or non-pneumothorax drained; heart disease (congenital or acquired); recent thoracic surgery (< 2 months); skin lesions on the chest wall or drains that prevent the use of the strap to data acquisition; severe brain injury and/or intracranial hypertension; refusal of parents or guardians to consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the plasma concentration of IL-6 48h after the onset of study. It is expected to find significantly lower levels of IL-6 in plasma and tracheal aspirate of patients in the intervention group. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected. | — |
Countries
Brazil
Contacts
Public ContactLeila Volpon
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo
Outcome results
None listed