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Effectiveness of Magnesium Sulphate for General Anesthesia in Adults

Effectiveness of magnesium sulphate compared to rocuronium for rapid sequence orotracheal intubation in adult patients

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
REBEC
Registry ID
RBR-4xr92k
Enrollment
Unknown
Registered
2017-08-02
Start date
2017-07-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute abdomen, Acute appendicitis

Interventions

All participants will receive the same anesthetic technique except for the medications that will characterize the group of their participation. All participants will receive 100% oxygen, venous access
Drug
D08.811.277.040.025.095

Sponsors

Centro Universitário Tiradentes
Lead Sponsor
Centro Universitário Tiradentes
Collaborator

Eligibility

Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patient diagnosed with acute appendicitis; Physical status ASA I and II; Age between 18 and 70 years.

Exclusion criteria

Exclusion criteria: Pregnancy; Neuromuscular disease; renal insufficiency; Body mass index greater than 30 km.m-2; Anticipation of difficulty in handling the airway; Chronic use of calcium channel blockers; Chronic use of medicines containing magnesium; Past allergy to magnesium sulfate.

Design outcomes

Primary

MeasureTime frame
Clinical condition of tracheal intubation. It will be verified by means of laryngoscopy, positioning of the vocal cords and reactions that the patient presents at the moment of passage of the orotracheal tube in the airways. It will be evaluated using the intubation score system of the Good Clinical Research Practice guidelines. It will be classified as an acceptable and unacceptable clinical condition. Unacceptable clinical condition will occur if laryngoscopy is difficult, vocal cords are closed, or if there is muscle reaction at the time of passage of the tube through the vocal cords. Classification is by visual inspection.

Secondary

MeasureTime frame
Heart rate, systemic blood pressure, adverse events and oxygen saturation. The heart rate will be verified by pulse oximetry and will be considered alteration when there is an increase or decrease of 10% of the initial value. Systemic blood pressure will be assessed using the sphygmomanometer. It is measured in mmHg and will be considered change when there is an increase or decrease of 10% of the initial value. The net research adverse events will be nausea, vomiting, hyperemia, arrhythmias and sweating. It will be collected through clinical observation. The arterial oxygen saturation will be collected by means of pulse oximetry and its value is shown in percentage number.

Countries

Brazil

Contacts

Public ContactFabiano Barbosa

Centro Universitário Tiradentes

fabianotimbo@yahoo.com.br+558299832054

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 28, 2026