Ozonized Sunflower Oil in Treating Tooth Sensitivity After Deep Cleaning: Randomized Clinical Study

Ozonized Sunflower Oil in the management of Dentin Hypersensitivity after Basic Periodontal Treatment: randomized clinical study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-4xqk4hv

Enrollment

Registered

2026-03-05

Start date

2024-03-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity Other specified diseases of hard tissues of teeth

Interventions

This is a randomized clinical trial with a split-mouth design in which for each participant one dental arch, either maxillary or mandibular, was allocated to the experimental group while the contralat

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients without systemic conditions or smoking habits, presenting periodontal pockets between 4 and 5 mm and sensitivity to evaporative stimuli, will be included; participants must not present gingival recession greater than 2 mm; must not have used dentin hypersensitivity control methods in the past 6 months; and must not use antibiotics during treatment; sensitivity measured on the Visual Analogue Scale (VAS) must be greater than 4 cm

Exclusion criteria

Exclusion criteria: Teeth with recent restorations; patients under chronic use of analgesics or psychotropic drugs; those wearing orthodontic appliances; or those who have undergone recent desensitizing treatment will be excluded; pregnant or breastfeeding women; as well as patients with occlusal dysfunctions, active carious lesions, or parafunctional habits, will also be excluded

Design outcomes

Primary

Measure	Time frame
Expected primary outcome 1: The primary outcome of this study is the reduction of dentin hypersensitivity, assessed using the Visual Analog Scale (VAS) and an adapted sensitivity scale ranging from 0 to 4, where 0 represents absence and 4 represents severe sensitivity. Evaluations were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. Statistical analysis considered intra- and intergroup comparisons using the paired t-test, based on mean differences between the experimental group (ozonated oil) and the control group.;Primary outcome found 1: A significant reduction in dentin hypersensitivity was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean score of 1.30 ± 0.95 on the sensitivity scale (0–4), whereas the control group showed a mean of 3.00 ± 0.94, with a statistically significant difference between groups (paired t-test; p < 0.001). These results indicate a greater reduction in dentin hypersensitivity with the adjunctive use of ozonated oil after basic periodontal therapy.	—

Measure

Time frame

Expected primary outcome 1: The primary outcome of this study is the reduction of dentin hypersensitivity, assessed using the Visual Analog Scale (VAS) and an adapted sensitivity scale ranging from 0 to 4, where 0 represents absence and 4 represents severe sensitivity. Evaluations were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. Statistical analysis considered intra- and intergroup comparisons using the paired t-test, based on mean differences between the experimental group (ozonated oil) and the control group.;Primary outcome found 1: A significant reduction in dentin hypersensitivity was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean score of 1.30 ± 0.95 on the sensitivity scale (0–4), whereas the control group showed a mean of 3.00 ± 0.94, with a statistically significant difference between groups (paired t-test; p < 0.001). These results indicate a greater reduction in dentin hypersensitivity with the adjunctive use of ozonated oil after basic periodontal therapy.

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Secondary

Measure	Time frame
Expected secondary outcome 1: The first secondary outcome is the reduction of the plaque index, assessed using the Silness-Löe Plaque Index. Measurements were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. The analysis compared groups regarding the percentage of surfaces with the presence of plaque.;Expected secondary outcome 2: The second secondary outcome is the reduction of the gingival bleeding index, assessed using the Gingival Bleeding Index by Saxton & Van der Ouderaa (1989). Evaluations were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. The analysis parameter considered the frequency of sites with a score greater than or equal to 1, comparing the experimental and control groups.;Expected secondary outcome 3: The third secondary outcome is the improvement in oral health-related quality of life, assessed through a self-reported questionnaire applied to patients. Evaluations were performed at baseline and after 60 days of treatment. The analysis considered the change in patients’ subjective perception of comfort and the impact of dentin hypersensitivity on daily routine.;Secondary outcome found 1: A significant reduction in plaque index was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean plaque index of 34.00 ± 17.76, whereas the control group showed a mean of 54.00 ± 20.11, with a statistically significant difference between groups (paired t-test; p = 0.004), indicating lower plaque accumulation in the ozonated oil group.;Secondary outcome found 2: A significant reduction in the gingival bleeding index was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean value of 15.00 ± 15.09, whereas the control group showed a mean of 36.00 ± 24.59, with a statistically significant difference between g	—

Measure

Time frame

Expected secondary outcome 1: The first secondary outcome is the reduction of the plaque index, assessed using the Silness-Löe Plaque Index. Measurements were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. The analysis compared groups regarding the percentage of surfaces with the presence of plaque.;Expected secondary outcome 2: The second secondary outcome is the reduction of the gingival bleeding index, assessed using the Gingival Bleeding Index by Saxton & Van der Ouderaa (1989). Evaluations were performed at baseline and after 7, 30, and 60 days following basic periodontal treatment. The analysis parameter considered the frequency of sites with a score greater than or equal to 1, comparing the experimental and control groups.;Expected secondary outcome 3: The third secondary outcome is the improvement in oral health-related quality of life, assessed through a self-reported questionnaire applied to patients. Evaluations were performed at baseline and after 60 days of treatment. The analysis considered the change in patients’ subjective perception of comfort and the impact of dentin hypersensitivity on daily routine.;Secondary outcome found 1: A significant reduction in plaque index was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean plaque index of 34.00 ± 17.76, whereas the control group showed a mean of 54.00 ± 20.11, with a statistically significant difference between groups (paired t-test; p = 0.004), indicating lower plaque accumulation in the ozonated oil group.;Secondary outcome found 2: A significant reduction in the gingival bleeding index was observed in the hemi-arch treated with ozonated sunflower oil compared with the control after 7 days. The experimental group presented a mean value of 15.00 ± 15.09, whereas the control group showed a mean of 36.00 ± 24.59, with a statistically significant difference between g

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Countries

Contacts

Public ContactMaria Ritha Colognese

Universidade Estadual do Oeste do Paraná

mariarithacolognese@gmail.com+55 (45) 99989-0377

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Apr 4, 2026