Serotonin 5ht3 receptors
Conditions
Interventions
-pain thresholds to hot and cold
this study’s objective was to evaluate ondansetron’s effect on mechanical and thermal pain thresholds, as well as CPM in humans.
17 volunteers, who were randomly selected and double blinded, partici
2 - NaCl at 0.9% and 8 mg ondansetron in a volume of 20 mL.
Before each intervention, the following basic tests were performed: Using the quantitative sensitivity test (QST) Algometer and TSA,2001
Medoc Ltd, we obtained:
-the thresholds for detecting warm and cold
-the pressure pain threshold.
-CPM was evaluated using the parallel paradigm in which two identical nociceptive test stimuli were induced before and simultaneous to a conditioned nociceptive stimulu
Drug
Device
D27.505.519.625.850.850.300
F02.830.816.781
C10.597.751.791.400
Sponsors
Universidade do Estado do Rio de Janeiro
Universidade do Estado do Rio de Janeiro
Eligibility
Inclusion criteria
Inclusion criteria: Healthy individuals of both sexes, aged between 18 and 60 years, with classification of physical status by the American Society of Anesthesiologists - ASA I, were invited to participate in the project.
Exclusion criteria
Exclusion criteria: Individuals with chronic pain, defined as pain lasting more than 3 months, of any origin were not included. as well as those who used analgesics, antidepressants, benzodiazepines or any drug with psychoactive action in the last 14 days prior to the tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1 - Evaluation of thermal and mechanical pain thresholds and conditioned pain modulation. Increase in heat detection threshold. Evaluated by semiquantitative sensory test (Medoc TSA-2001; Medoc Ltd., Ramat Yishai, Israel). Verified by Wilcoxon statistical test, with p 0.05%);Expected outcome 3: Evaluation of mechanical pain thresholds - There was no statistical significance (p> 0.05%).;Expected outcome: Evaluation of pain-conditioned modulation - Ondansetron improved CPM, with statistical significance (p >0.05%). | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome found 1: The results, in our series, revealed an increase in the threshold of thermal detection and heat pain, with the use of ondansetron (P 0.05%).;Outcome found 4: Evaluation of conditioned pain modulation. There was an improvement in CPM, after the administration of ondansetron, with statistical significance ( p > 0.05%). This suggests a central role occasioned by serotonergic antagonism (5HT3) | — |
Countries
Brazil
Contacts
Public ContactBruno Santiago
Universidade do Estado do Rio de Janeiro
Outcome results
None listed