Periodontitis
Conditions
Interventions
This is a randomized, controlled, two-arm, double-blind clinical trial. The experimental group will consist of 43 adult individuals with stage III or IV periodontitis, in the maintenance phase of peri
G07.203.300.456.500
G07.203.300.456
Sponsors
Faculdade de Odontologia da Universidade de São Paulo
Faculdade de Odontologia da Universidade de São Paulo
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Being man or woman. Having stage III or IV periodontitis. Having received treatment for active periodontitis, including mechanical therapy with or without antibiotic therapy using amoxicillin and metronidazole, at the clinic of the School of Dentistry, University of São Paulo. Currently being in the supportive periodontal therapy phase. Being in good general health. Having at least six teeth present in the oral cavity, with at least one non-adjacent interproximal site presenting probing depth (PD) and clinical attachment level (CAL) equal to or greater than 5mm. Being over 18 years of age
Exclusion criteria
Exclusion criteria: Presenting any systemic condition that may influence the course of periodontal disease, such as diabetes, or that requires the use of systemic antibiotics. Being a smoker. Having a Body Mass Index (BMI) greater than 30 kilograms per square meter. Being pregnant or breastfeeding. Having used systemic antibiotics in the three months prior to the beginning of the study. Frequently using mouthwashes. Regularly consuming probiotic products. Being under 18 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessing the mean reduction in probing depth (PD) at 3 months, considering all probed periodontal sites. Statistical analyses will be performed to determine the presence or absence of statistically significant differences between the groups and between the experimental time points, with the results presented in tables. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the clinical parameters of mean bleeding on probing (considering all probed sites) and the mean full-mouth plaque index, obtained through completion of the periodontal chart at baseline and after three months. Statistical analyses will be performed to determine the presence or absence of statistically significant differences between the groups and between the experimental time points, with the results presented in tables. Salivary levels of pro- and anti-inflammatory cytokines, chemokines, and MMP-8 will be measured using enzyme-linked immunosorbent assay (ELISA), followed by statistical analysis to identify any significant differences between groups and time points, with the data presented in graphical format. | — |
Countries
Brazil
Contacts
Public ContactMarcia Mayer
Faculdade de Odontologia da Universidade de São Paulo
Outcome results
None listed